CM03
Based on 1 publication(s) in Google Scholar
CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.23%
- CAS 番号: 2101208-44-8
- 分子式: C34H44N6O6
- 分子量:632.75
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 CM03
MoreDNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
DNA synthesis[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
24 nM
Compound: CM03
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Growth inhibition of human A549 cells after 96 hrs by SRB assay
Growth inhibition of human A549 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
| BXPC-3 | GI50 |
15.5 nM
Compound: CM03
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Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay
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[PMID: 32832034] |
| BXPC-3 | IC50 |
19 nM
Compound: CM03
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Growth inhibition of human BxPC3 cells after 96 hrs by SRB assay
Growth inhibition of human BxPC3 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
| CAPAN-1 | GI50 |
26.5 nM
Compound: CM03
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Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay
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[PMID: 32832034] |
| CAPAN-1 | IC50 |
16 nM
Compound: CM03
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Growth inhibition of human Capan1 cells after 96 hrs by SRB assay
Growth inhibition of human Capan1 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
| MCF7 | IC50 |
159 nM
Compound: CM03
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Growth inhibition of human MCF7 cells after 96 hrs by SRB assay
Growth inhibition of human MCF7 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
| MIA PaCa-2 | GI50 |
400 nM
Compound: CM03
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Growth inhibition of human MIAPaCa2 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
Growth inhibition of human MIAPaCa2 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 29356532] |
| MIA PaCa-2 | GI50 |
9 nM
Compound: CM03
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Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
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[PMID: 32832034] |
| MIA PaCa-2 | IC50 |
7 nM
Compound: CM03
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Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay
Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
| PANC-1 | GI50 |
15.6 nM
Compound: CM03
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Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay
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[PMID: 32832034] |
| PANC-1 | GI50 |
400 nM
Compound: CM03
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Growth inhibition of human PANC1 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
Growth inhibition of human PANC1 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 29356532] |
| PANC-1 | IC50 |
18 nM
Compound: CM03
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Growth inhibition of human PANC1 cells after 96 hrs by SRB assay
Growth inhibition of human PANC1 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
| WI-38 | IC50 |
1190 nM
Compound: CM03
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Growth inhibition of human WI38 cells after 96 hrs by SRB assay
Growth inhibition of human WI38 cells after 96 hrs by SRB assay
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[PMID: 29356532] |
体外実験
CM03 (0.4 μM; 24 or 48 h) increases the level of γ-H2AX protein when in combination with SAHA (HY-10221) in MIA PaCa-2 and PANC-1[1].
CM03 (0-100 nM; 96 h) exhibits highly anti-proliferative activity against pancreatic cancer cell lines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:MIA PaCa-2 and PANC-1
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Concentration:0.4 μM
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Incubation Time:24 h for MIA PaCa-2, 48 h for PANC-1
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Result:Significantly increased the level of γ-H2AX protein when in combination with SAHA (HY-10221) (1 μM).
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Cell Line:MIA PaCa-2, PANC-1, Capan-1 and BxPC-3
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Concentration:0-100 nM
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Incubation Time:96 h
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Result:Exhibited highly anti-proliferative activity against pancreatic cancer cell lines with GI50s of 9.0 nM, 15.6 nM, 26.5 nM and 15.5 nM in MIA PaCa-2, PANC-1, Capan-1 and BxPC-3, respectively.
化学情報
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CAS 番号 2101208-44-8
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性状 Solid
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分子量 632.75
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分子式 C34H44N6O6
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Color Brown to dark brown
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SMILES
O=C(C1=CC=C2C3=O)N(C(C4=C1C2=C(C=C4NCCN5CCCC5)C(N3CCCN6CCOCC6)=O)=O)CCCN7CCOCC7
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
体外:
DMSO : 2 mg/mL (3.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ahmed AA, et al. A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells. Molecules. 2020 Nov 19;25(22):5407. [Content Brief]
[2]. Ahmed AA, et al. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5804 mL | 7.9020 mL | 15.8040 mL | 39.5101 mL |
CM03 関連分類
HY-121862 関連分類
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