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製品番号: HY-112942

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CMP-Sialic acid

(別名: CMP-Neu5Ac)

3 Cited Publications

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.

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CAS 番号: 3063-71-6
分子式: C₂₀H₃₁N₄O₁₆P
分子量:614.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

CMP-Sialic acid 構造式

CAS 番号: 3063-71-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

Human Endogenous Metabolite

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

体外実験

CMP-Sialic acid (22.5 μM, 45 min) can be used as a CMAH substrate to detect the formation of Neu5Gc in platelet lysates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3063-71-6
分子量 614.45
分子式 C₂₀H₃₁N₄O₁₆P
SMILES

O[C@@H]1[C@H](O[C@@H](N2C(N=C(N)C=C2)=O)[C@@H]1O)COP(O[C@@]3(O[C@@]([C@H](NC(C)=O)[C@@H](O)C3)([H])[C@H](O)[C@H](O)CO)C(O)=O)(O)=O
別名

CMP-Neu5Ac
Structure Classification
- Others
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

All In Vivo Efficacy StudyELISA

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Adv Mater

Shutting Down the 'Language Encoder': A Pathogen-Derived Nano-Interferer Disrupt Sialylation Metabolism and Reprogram Intercellular Communication in Glioblastoma. [Abstract]

2025 Nov 29:e16608. PMID: 41316829
Cell Host Microbe

Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism. [Abstract]

2025 Jul 9;33(7):1133-1145.e4. PMID: 40494348

CMP-Sialic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]

CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 d), the product of CMAS, enhanced gonococcal burden in C57BL/6 J WT and Ifnε^−/− mice when administered intravaginally.

CMP-Sialic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]

Intravaginal CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 days) instillation restored LOS sialylation in Ifnε^−/− and anti-IFNAR-treated mice.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5. [Content Brief]

[2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.

[3]. Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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濃度 _(開始) 濃度 _(開始)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

CMP-Sialic acid

3 Cited Publications

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
Publications (3)
純度とドキュメンテーション
参考文献

1/16
1/16

CMP-Sialic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]

Customer Validation
CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 d), the product of CMAS, enhanced gonococcal burden in C57BL/6 J WT and Ifnε^−/− mice when administered intravaginally.
1/16

CMP-Sialic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]

Customer Validation
Intravaginal CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 days) instillation restored LOS sialylation in Ifnε^−/− and anti-IFNAR-treated mice.

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CMP-Sialic acid

MedChemExpress（MCE）の使用を引用している文献 CMP-Sialic acid

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (3)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

CMP-Sialic acid 関連分類

HY-112942 関連分類