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製品番号: HY-N10367

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Corydamine

Corydamine, 3-arylisoquinoline alkaloid, is a potent DNA topoisomerase I/II inhibitor. Corydamine has anti-cancer activity.

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CAS 番号: 49870-84-0
分子式: C₂₀H₁₈N₂O₄
分子量:350.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Corydamine 構造式

CAS 番号: 49870-84-0

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Corydamine, 3-arylisoquinoline alkaloid, is a potent DNA topoisomerase I/II inhibitor. Corydamine has anti-cancer activity^[1].

IC₅₀ & Target^[1]

Topoisomerase I

Topoisomerase II

Topoisomerase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
BGC-823	IC₅₀	25.92 μM Compound: 1	Antiproliferative activity against human BGC-823 cells after 72 hrs by MTT assay Antiproliferative activity against human BGC-823 cells after 72 hrs by MTT assay	[PMID: 34802836]
HCCLM9	IC₅₀	10.02 μM Compound: 1	Antiproliferative activity against human HCCLM9 cells after 72 hrs by MTT assay Antiproliferative activity against human HCCLM9 cells after 72 hrs by MTT assay	[PMID: 34802836]
HCT-116	IC₅₀	>150 μM Compound: 1	Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay	[PMID: 34802836]
HepG2	IC₅₀	45 μM Compound: 1	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 34802836]
HGC-27	IC₅₀	20.91 μM Compound: 1	Antiproliferative activity against human HGC-27 cells after 72 hrs by MTT assay Antiproliferative activity against human HGC-27 cells after 72 hrs by MTT assay	[PMID: 34802836]
HL-60	IC₅₀	112.8 μM Compound: 1	Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay	[PMID: 34802836]
HT-29	IC₅₀	23 μM Compound: 1	Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 34802836]
Huh-7	IC₅₀	15.51 μM Compound: 1	Antiproliferative activity against human Huh-7 cells after 72 hrs by MTT assay Antiproliferative activity against human Huh-7 cells after 72 hrs by MTT assay	[PMID: 34802836]
L02	IC₅₀	>150 μM Compound: 1	Antiproliferative activity against human L02 cells after 72 hrs by MTT assay Antiproliferative activity against human L02 cells after 72 hrs by MTT assay	[PMID: 34802836]
MCF7	IC₅₀	49.9 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 34802836]
MDA-MB-231	IC₅₀	19.3 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 34802836]
RKO	IC₅₀	63.5 μM Compound: 1	Antiproliferative activity against human RKO cells after 72 hrs by MTT assay Antiproliferative activity against human RKO cells after 72 hrs by MTT assay	[PMID: 34802836]
SGC-7901	IC₅₀	10620 μM Compound: 1	Antiproliferative activity against human SGC-7901 cells after 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells after 72 hrs by MTT assay	[PMID: 34802836]
SK-HEP1	IC₅₀	28.19 μM Compound: 1	Antiproliferative activity against human SK-HEP1 cells after 72 hrs by MTT assay Antiproliferative activity against human SK-HEP1 cells after 72 hrs by MTT assay	[PMID: 34802836]
SW480	IC₅₀	25.4 μM Compound: 1	Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay	[PMID: 34802836]
U-251	IC₅₀	19.1 μM Compound: 1	Antiproliferative activity against human U-251 cells after 72 hrs by MTT assay Antiproliferative activity against human U-251 cells after 72 hrs by MTT assay	[PMID: 34802836]

化学情報

CAS 番号 49870-84-0
分子量 350.37
分子式 C₂₀H₁₈N₂O₄
SMILES

CNCCC1=C(C2=CC3=C(C=N2)C(OCO4)=C4C=C3)C=C(OCO5)C5=C1
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xuemei Deng, et al. Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids. Eur J Med Chem. 2022 Jan 15;228:113985. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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Corydamine

Topoisomerase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Corydamine 関連分類

HY-N10367 関連分類