CP-775146
Based on 1 Customer Validation
CP-775146 is a selective PPARα agonist (Ki of 24.5 nM) that binds strongly to the PPARα ligand. CP-775146 has no observable affinity for PPARβ and PPARγ.CP-775146 shows hypolipidemic activity. CP-775146 efficiently alleviates obesity-induced liver damage, prevents lipid accumulation by activating the liver fatty acid β-oxidation pathway.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.70%
- CAS 番号: 702680-17-9
- 分子式: C26H33NO4
- 分子量:423.54
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice (4-week-old) with a high-fat diet (HFD)[2]
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Dosage:0.1 mg/kg, 0.3 mg/kg
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Administration:Intraperitoneal injection (i.p.); daily; for 3 days
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Result:Reduced the serum levels of liver enzymes, such as ALT and AST and lipid metabolism-related biomarkers, including TGs and LDL-c, non-HDL-c, and hepatic TG content, at a dosage of 0.1 mg/kg.
HFD-induced pathological liver changes improved.
The expression of genes involved in liver fatty acid oxidation (Acadl, Acox-1, CPT-1, and Ehhadh) was upregulated.
Induced the expression of thermogenesis genes (Cidea, Ucp1) and lipolysis genes (Hsl, Atgl).
化学情報
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CAS 番号 702680-17-9
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性状 Solid
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分子量 423.54
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分子式 C26H33NO4
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Color White to off-white
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SMILES
CC(OC1=CC=CC([C@H]2CN(C(CC3=CC=C(C(C)C)C=C3)=O)CCC2)=C1)(C)C(O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 42 mg/mL (99.16 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kane CD, et al. Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo. Mol Pharmacol. 2009 Feb;75(2):296-306. [Content Brief]
[2]. Shengjie Tang, et al. The Effects of New Selective PPAR α Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism. J Diabetes Res. 2020 May 4;2020:4179852. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3611 mL | 11.8053 mL | 23.6105 mL | 59.0263 mL |
| 5 mM | 0.4722 mL | 2.3611 mL | 4.7221 mL | 11.8053 mL | |
| 10 mM | 0.2361 mL | 1.1805 mL | 2.3611 mL | 5.9026 mL | |
| 15 mM | 0.1574 mL | 0.7870 mL | 1.5740 mL | 3.9351 mL | |
| 20 mM | 0.1181 mL | 0.5903 mL | 1.1805 mL | 2.9513 mL | |
| 25 mM | 0.0944 mL | 0.4722 mL | 0.9444 mL | 2.3611 mL | |
| 30 mM | 0.0787 mL | 0.3935 mL | 0.7870 mL | 1.9675 mL | |
| 40 mM | 0.0590 mL | 0.2951 mL | 0.5903 mL | 1.4757 mL | |
| 50 mM | 0.0472 mL | 0.2361 mL | 0.4722 mL | 1.1805 mL | |
| 60 mM | 0.0394 mL | 0.1968 mL | 0.3935 mL | 0.9838 mL | |
| 80 mM | 0.0295 mL | 0.1476 mL | 0.2951 mL | 0.7378 mL |
CP-775146 関連分類
HY-108571 関連分類
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