cPP12-2-Lys
cPP12-2-Lys is a cyclic cell-penetrating peptide that serves as a negative control, i.e., it lacks any NatD bisubstrate moiety. cPP12-2-Lys is not a NatD inhibitor (IC50 = 9500 nM), but it possesses excellent cell-penetrating ability and can mediate the entry of conjugated bisubstrate inhibitors into non-small cell lung cancer (NSCLC) cells. cPP12-2-Lys can be used in NSCLC research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C64H95N23O10S
- 分子量:1378.65
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
cPP12-2-Lys (0.15 nM-30 μM; 30 min) alone shows very weak inhibitory activity against purified NatD enzyme with an IC50 of 9500 nM[1].
cPP12-2-Lys (5 μM; 2 h) is taken up by A549 non-small cell lung cancer cells, but at lower levels than its bisubstrate inhibitor-conjugated counterpart[1].
cPP12-2-Lys (up to 10 μM; 48 h) does not reduce viability of A549 and H1299 non-small cell lung cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 1378.65
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分子式 C64H95N23O10S
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配列
Cyclo(Phe-d{Phe}-{Bta}-Arg-d{Arg}-Arg-d{Arg}-Gln)-Lys
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シーケンスの短縮
Cyclo(F-d{Phe}-{Bta}-R-d{Arg}-R-d{Arg}-Q)-K
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
cPP12-2-Lys 関連分類
HY-P11856 関連分類
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