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United States

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製品番号: HY-P992511

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CS2009

CS2009 is a trispecific antibody targeting PD-1, CTLA-4 and VEGFA. CS2009 blocks the interactions of PD-1/PD-L1, CTLA-4/CD80 and VEGFA/VEGFR2, mediates checkpoint inhibition, and suppresses tumor angiogenesis. CS2009 reactivates PD-1/CTLA-4 double-positive tumor-infiltrating T lymphocytes, induces T cell activation, enhances tumor growth inhibition, promotes vascular normalization, improves T lymphocyte infiltration, and converts the immunosuppressive tumor microenvironment into an immunocompetent one. CS2009 can be used for the research of various advanced solid tumors.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CS2009 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Species Reactivity
- 体外実験
- 遺伝子ID
- アクセッション番号
- Target
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Species Reactivity

Human

VEGFR アイソフォーム固有の製品をすべて表示 :

体外実験

CS2009 preferentially targets and activates PD-1/CTLA-4 double-positive tumor-infiltrating T lymphocytes (TILs); its anti-VEGFA arm inhibits tumor angiogenesis and promotes vascular normalization, which helps convert the immunosuppressive tumor microenvironment (TME) into an immunocompetent TME, thereby enhancing effector TIL-mediated tumor growth inhibition^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

遺伝子ID

29126 [NCBI] & 7422 [NCBI] & 1493 [NCBI]

アクセッション番号

Q9NZQ7 & P15692 & P16410

Target

PD-1 & VEGF & CTLA-4

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

アプリケーション

ELISA, FACS, Functional assay

化学情報

Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Wang C, et al. CS2009: A first-in-class trispecific antibody targeting PD-1, CTLA-4, and VEGFA with potential to be a next-generation backbone therapy with combined checkpoint inhibition and anti-angiogenesis. Cancer Research. 2025 Apr 21;85(8_Supplement_1):7299-.

[2]. Wang C, et al. 504 CS2009, a novel first-in-class trispecific antibody targeting PD-1, CTLA-4, and VEGFa, demonstrates promising anti-tumor activity in preclinical evaluation.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- Species Reactivity
- 体外実験
- 遺伝子ID
- アクセッション番号
- Target
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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製品名:
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CS2009

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

VEGFR アイソフォーム固有の製品をすべて表示