Copy Link Print Information

CU-CPT 4a

(別名: TLR3-IN-1)
13 Cited Publications
カスタマーレビュー

Based on 13 publication(s) in Google Scholar

CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.50%
  • CAS 番号: 1279713-77-7
  • 分子式: C18H13ClFNO3S
  • 分子量:377.82
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • CU-CPT 4a Chemical Structure
    CU-CPT 4a 構造式
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
  • Experimental Validation Results for CU-CPT 4a
CAS 番号: 1279713-77-7
容量
価格（税別）
在庫状況
数量
Amount: USD 0.00
Please select quantity
or
or

* アイテムを追加する前、数量をご選択ください

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of CU-CPT 4a:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
  • 生物活性
  • 化学情報
  • 溶剤 & 溶解度
  • プロトコル
  • 純度とドキュメンテーション
  • 参考文献
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

MedChemExpress（MCE）の使用を引用している文献 CU-CPT 4a

More
Customer Validation & Images
Cell Imaging/StainingIn Vivo Efficacy StudyWBHistological Imaging/StainingELISA
  • WB
  • ELISA
  • In Vivo Efficacy Study
  • In Vivo Efficacy Study
  • Histological Imaging/Staining
  • WB
  • Cell Imaging/Staining
  • Cell Imaging/Staining

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示

More
Keywords
MOQ
Minimum order quantity
100 mg

お問い合わせ 在庫あり

Other size
お問い合わせ
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress ログイン
Register
Sign in to MedChemExpress
新規会員登録

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • CU-CPT 4a Chemical Structure
    CU-CPT 4a Chemical Structure
    1/16
  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 May;14(5):e70083. [Abstract]

    Customer Validation
     m6A levels in EVs regulate inflammatory responses via TLR8 in macrophages. Differentiated THP‐1 cells (dTHP‐1) were pretreated with or without CU‐CPT‐9a (HY-112667; 48 h) and CU‐CPT‐4a (HY-108473; 48 h). Whole‐cell lysates obtained from dTHP‐1 cells were subjected to Western blot analysis using an anti‐phospho p65 antibody, anti‐p65 antibody and anti‐β‐actin antibody. Representative images from three independent experiments are shown.

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 May;14(5):e70083. [Abstract]

    Customer Validation
     m6A levels in EVs regulate inflammatory responses via TLR8 in macrophages. Differentiated THP‐1 cells (dTHP‐1) were pretreated with or without CU‐CPT‐9a (HY-112667; 48 h) and CU‐CPT‐4a (HY-108473; 48 h). Conditioned medium from dTHP‐1 cells treated with CCD‐841‐CoN or HT29 small EVs was used for ELISA. dTHP‐1 cells were pre‐transfected with or without TLR8 siRNA.

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Mol Pain. 2025 Jan-Dec:21:17448069251346373. [Abstract]

    Customer Validation
     TLR3 antagonist CU CPT4a inhibited NTG-induced mechanical allodynia. Repeated treatment with CU CPT4a (5 mg/kg, i.p.) or vehicle (equal volumes of DMSO) every other day before NTG injections for 9 days. Repeated treatment with CU CPT4a inhibited basal hind paw mechanical and periorbital mechanical allodynia.

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Mol Pain. 2025 Jan-Dec:21:17448069251346373. [Abstract]

    Customer Validation
     TLR3 antagonist CU CPT4a inhibited NTG-induced mechanical allodynia. Repeated treatment with CU CPT4a (5 mg/kg, i.p.) or vehicle (equal volumes of DMSO) every other day before NTG injections for 9 days. Post-treatment responses, including hind paw mechanical and periorbital mechanical allodynia, were estimated 2 h after NTG administration.

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Mol Pain. 2025 Jan-Dec:21:17448069251346373. [Abstract]

    Customer Validation
     TLR3 antagonist CU CPT4a (5 mg/kg; i.p.; every other day for 9 days before NTG injection) reduced the expression of TLR3 in TNC. Quantitative analysis of the number of TLR3+Neuron in the TNC in a 212 × 212 µm² visual field of each section per mouse after NTG injection.

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Mol Pain. 2025 Jan-Dec:21:17448069251346373. [Abstract]

    Customer Validation
     TLR3 antagonist CU CPT4a (5 mg/kg; i.p.; every other day for 9 days before NTG injection) reduced the expression of TLR3 in TNC. Immunoblot analysis of TLR3 (n = 5).

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Nov 3;14(1):7048. [Abstract]

    Customer Validation
     Immunofluorescence images of MMP21 in the absence or presence of RIG012 or CU-CPT 4a. β-cat ΔN/RasV12 cells were mixed with β-cat ΔN cells in the presence of BFA, and were treated with DMSO, 2.5 μM RIG012 or 50 μM CU-CPT 4a. Cells were stained with Hoechst 33342 (blue) and anti-MMP21 antibody (white).

  • 1/16

    CU-CPT 4a purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Nov 3;14(1):7048. [Abstract]

    Customer Validation
     Immunofluorescence images of MMP21 or p65 in intestinal organoids from APCMin-Villin-RasV12 mice in the absence or presence of 10 μM RIG012 or 100 μM CU-CPT 4a.

  • CU-CPT 4a