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United States

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製品番号: HY-175828

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DHPS-IN-2

DHPS-IN-2 is an allosteric deoxyhypusine synthase (DHPS) inhibitor with an IC₅₀ of 70 nM and a K_d of 26.4 μM. DHPS-IN-2 significantly suppresses melanoma cell migration and invasiveness in vitro and exhibits potent anti-tumor efficacy in an A375 cell zebrafish xenograft model. DHPS-IN-2 can be used for the study of melanoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₇H₁₅IN₂O₂
分子量:406.22

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

DHPS-IN-2 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

DHPS-IN-2 (Compound 7C16) inhibits A375 and B16 cell proliferation with IC₅₀ of 4.0 and 14.4 μM, and has a low cytotoxicity towards normal HaCaT cells (CC₅₀ = 16.6 μM)^[1].
DHPS-IN-2 (1-10 μM) significantly inhibits the invasion and migration abilities of A375 cells^[1].
DHPS-IN-2 (1-10 μM, 24 h) inhibits melanoma proliferation by modulating the expression of melanoma-associated proteins (elF5A-Hyp) in A375 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

A375 cells
Concentration:

1, 5 and 10 μM
Incubation Time:

24 h
Result:

Significantly reduced the level of eIF5A-Hyp.
Reduced the melanoma markers GP-100 and tyrosinase.
Did not affect the total expression of DHPS protein.

体内実験

DHPS-IN-2 (Compound 7C16) (15.6 μM, 7 days) exhibits potent anti-melanoma activity in zebrafish xenograft models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

A375 cells were fluorescently labeled with CM-DiI and Xenograft via microinjection into the yolk sac of 2 dpf wild-type AB strain zebrafish^[1]
Dosage:

15.6 μM
Administration:

7 days
Result:

Exhibited superior antitumor efficacy at lower concentrations.

化学情報

分子量 406.22
分子式 C₁₇H₁₅IN₂O₂
SMILES

IC1=CC=C(C=C1)CC2=NN=C(CC3=CC=CC=C3OC)O2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Liu KL, et al. In silico design, synthesis and biological evaluation of 2-benzyl-5-(2-methoxybenzyl)-1,3,4-oxadiazole derivates as allosteric deoxyhypusine synthase (DHPS) inhibitors for melanoma treatment. Eur J Med Chem. 2025 Dec 5;299:118061. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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