Dihydrostreptomycin
Dihydrostreptomycin (DHSM) is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 128-46-1
- 分子式: C23H45N7O12
- 分子量:611.64
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Antibiotic アイソフォーム固有の製品をすべて表示
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生物活性
Dihydrostreptomycin blocks mechanoelectric transduction channels, induces increased intracellular calcium concentrations, and leads to the obstruction of auditory signal transmission[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse models[2]
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Dosage:600 mg/kg
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Administration:ip, once daily for 12 days
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Result:Upregulated the expression of FGF receptors and connexin 43, increased the number of BrdU-positive cells in the spiral ligament.
化学情報
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CAS 番号 128-46-1
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分子量 611.64
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分子式 C23H45N7O12
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SMILES
CN[C@H]1[C@@H]([C@H]([C@@H](O[C@@]1(C)O[C@H]2[C@H](O[C@H]([C@@]2(CO)O)C)O[C@@]3(C)[C@@H]([C@H]([C@@H]([C@H]([C@@H]3NC(N)=N)O)NC(N)=N)O)O)CO)O)O
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別名
DHSM
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Marcotti W, et al. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol. 2005 Sep 1;567(Pt 2):505-21. [Content Brief]
[2]. Yamashita H, et al., Cell proliferation in spiral ligament of mouse cochlea damaged by dihydrostreptomycin sulfate. Acta Otolaryngol. 1999;119(3):322-5. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dihydrostreptomycin 関連分類
HY-B1241A 関連分類
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