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DIM-C-pPhOH

9 Cited Publications
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Based on 9 publication(s) in Google Scholar

DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively.

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  • 純度: 98.88%
  • CAS 番号: 151358-47-3
  • 分子式: C23H18N2O
  • 分子量:338.40
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • DIM-C-pPhOH Chemical Structure
    DIM-C-pPhOH 構造式
  • Experimental Validation Results for DIM-C-pPhOH
  • Experimental Validation Results for DIM-C-pPhOH
  • Experimental Validation Results for DIM-C-pPhOH
  • Experimental Validation Results for DIM-C-pPhOH
  • Experimental Validation Results for DIM-C-pPhOH
CAS 番号: 151358-47-3
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  • DIM-C-pPhOH Chemical Structure
    DIM-C-pPhOH Chemical Structure
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    DIM-C-pPhOH purchased from MedChemExpress. Usage Cited in: Transl Neurodegener. 2025 Jun 4;14(1):29. [Abstract]

    Customer Validation
     The recognition index for the new object recorded over a 24 h period in the NOR test (n = 6–8 animals/group). DIM-C-pPhOH (DIM-C, 50 mg/kg; i.p.; once daily for 1 week) treatment substantially increased the cognitive discrimination index of C57BL/6J mice compared to the AAV-siYAP1 group.

  • 1/16

    DIM-C-pPhOH purchased from MedChemExpress. Usage Cited in: Transl Neurodegener. 2025 Jun 4;14(1):29. [Abstract]

    Customer Validation
     Golgi staining and quantitation of spine number in the dentate gyrus of the hippocampus (n = 5 animals/group).The results showed that DIM-C-pPhOH (DIM-C, 50 mg/kg; i.p.; once daily for 1 week) alleviated YAP1 deletion-triggered dendritic spine loss in C57BL/6J mice.

  • 1/16

    DIM-C-pPhOH purchased from MedChemExpress. Usage Cited in: Transl Neurodegener. 2025 Jun 4;14(1):29. [Abstract]

    Customer Validation
     DIM-C-pPhOH (DIM-C, 50 mg/kg; i.p.; once daily for 1 week) partially reversed YAP1-induced reduction of synapse-related proteins (PSD95 and synaptophysin) in the hippocampus of C57BL/6J mice via inhibiting Nr4a1.

  • 1/16

    DIM-C-pPhOH purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Sep 10:S2090-1232(25)00701-5. [Abstract]

    Customer Validation
     Echocardiography analysis of representative B-model sonography of different groups of mice on the 14th day after Sham and MI. The results demonstrated that NR4a1 inhibition by DIM-C-pPhOH (DIM-C; 50 mg/kg; i.p.) counteracted the detrimental effects of SAMHD1 overexpression on post-MI cardiac function.

  • 1/16

    DIM-C-pPhOH purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Sep 10:S2090-1232(25)00701-5. [Abstract]

    Customer Validation
     mRNA levels of Arg1 and Nos2 in heart tissues of different groups of mice on day 3 after Sham and MI (n=6). The results revealed that DIM-C-pPhOH (DIM-C; 50 mg/kg; i.p.) treatment reversed the SAMHD1 overexpression-induced suppression of the cardiac reparative factor Arg1 and reversed the upregulation of the proinflammatory factor Nos2.

  • DIM-C-pPhOH