Dinaline
Dinaline (GOE 1734; PD 104 208; NSC 328786) is a potent and orally activity anticancer agent. Dinaline shows cytotoxicity and antitumor activity. Dinaline has the potential for the research of colorectal cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 58338-59-3
- 分子式: C13H13N3O
- 分子量:227.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
12.6 μM
Compound: Dinaline
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Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
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[PMID: 20966043] |
| HepG2 | EC50 |
28.2 μM
Compound: Dinaline
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Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
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[PMID: 20966043] |
Dinaline (0.47-15 µg/mL; 48, 27 h) shows cytotoxicity for SW707, SW948 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW707, SW948 cells
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Concentration:0.47, 0.95, 1.9, 3.8, 7.5, 15 µg/mL
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Incubation Time:48, 72 h
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Result:Inhibited cell growth with IC50s of 2.2, 1.0 µg/mL at 48 h and 1.2, 0.8 µg/mL at 72 h for SW707, SW948 cells, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:140-160 g, male Sprague-Dawley rats[1]
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Dosage:5.9, 7.7, 10 mg/kg
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Administration:P.o.; 5 days per week for 10 weeks
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Result:Showed significant tumor growth inhibition in a dose-dependent manner with the ratio of median tumor volume of (T/C%) values of 0.4, 16 and 10.6 at 10, 7.7 and 5.9 mg/kg respectively.
化学情報
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CAS 番号 58338-59-3
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分子量 227.26
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分子式 C13H13N3O
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SMILES
O=C(C1=CC=C(C=C1)N)NC2=C(N)C=CC=C2
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別名
GOE 1734; PD 104 208; NSC 328786
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Dinaline 関連分類
HY-W326094 関連分類
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