DM3
Based on 1 Customer Validation
DM3 (Maytansinoid DM3), a Maytansine (HY-13674) analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.59%
- CAS 番号: 796073-54-6
- 分子式: C37H52ClN3O10S
- 分子量:766.34
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Maytansinoids |
DM3 contains disulfide bonds or thiol groups, which can be covalently linked to monoclonal antibodies (mAb)[1].
DM3 exerts a strong anti-mitotic effect by inhibiting microtubule dynamic instability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 796073-54-6
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性状 Solid
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分子量 766.34
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分子式 C37H52ClN3O10S
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Color White to off-white
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SMILES
C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(S)C)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
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別名
Maytansinoid DM3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (130.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [Content Brief]
[2]. Griffin P, et al. High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model. Cancer Cell Int. 2023 Apr 5;23(1):60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3049 mL | 6.5245 mL | 13.0490 mL | 32.6226 mL |
| 5 mM | 0.2610 mL | 1.3049 mL | 2.6098 mL | 6.5245 mL | |
| 10 mM | 0.1305 mL | 0.6525 mL | 1.3049 mL | 3.2623 mL | |
| 15 mM | 0.0870 mL | 0.4350 mL | 0.8699 mL | 2.1748 mL | |
| 20 mM | 0.0652 mL | 0.3262 mL | 0.6525 mL | 1.6311 mL | |
| 25 mM | 0.0522 mL | 0.2610 mL | 0.5220 mL | 1.3049 mL | |
| 30 mM | 0.0435 mL | 0.2175 mL | 0.4350 mL | 1.0874 mL | |
| 40 mM | 0.0326 mL | 0.1631 mL | 0.3262 mL | 0.8156 mL | |
| 50 mM | 0.0261 mL | 0.1305 mL | 0.2610 mL | 0.6525 mL | |
| 60 mM | 0.0217 mL | 0.1087 mL | 0.2175 mL | 0.5437 mL | |
| 80 mM | 0.0163 mL | 0.0816 mL | 0.1631 mL | 0.4078 mL | |
| 100 mM | 0.0130 mL | 0.0652 mL | 0.1305 mL | 0.3262 mL |
DM3 関連分類
HY-130080 関連分類
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