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製品番号: HY-133030

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DNMT-IN-1

DNMT-IN-1 is a potent DNMT inhibitor with an EC₅₀ value of 3.2 µM. DNMT-IN-1 shows antiproliferative active.

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CAS 番号: 2396691-28-2
分子式: C₁₅H₉BrN₂O₆
分子量:393.15

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

DNMT-IN-1 構造式

CAS 番号: 2396691-28-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

DNMT-IN-1 is a potent DNMT inhibitor with an EC₅₀ value of 3.2 µM. DNMT-IN-1 shows antiproliferative active^[1].

IC₅₀ & Target^[1]

DNA Methyltransferase

3.2 μM (EC₅₀)

DNA Methyltransferase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	EC₅₀	10.7 μM Compound: 3b	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by APTlite one step luminescence assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by APTlite one step luminescence assay	[PMID: 31757526]
KG-1	EC₅₀	13 μM Compound: 3b	Cytotoxicity against human KG-1 cells assessed as reduction in cell viability measured after 72 hrs by APTlite one step luminescence assay Cytotoxicity against human KG-1 cells assessed as reduction in cell viability measured after 72 hrs by APTlite one step luminescence assay	[PMID: 31757526]

体外実験

DNMT-IN-1 (compound 3b) shows antiproliferative active with EC₅₀s of 13.0, 10.7 µM for KG1, HCT116 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

KG1, HCT116 cells
Concentration:

0-100 µM
Incubation Time:

72 h
Result:

Showed antiproliferative active with EC₅₀s of 13.0, 10.7 µM for KG1, HCT116 cells, respectively.

化学情報

CAS 番号 2396691-28-2
分子量 393.15
分子式 C₁₅H₉BrN₂O₆
SMILES

Br[C@@]1([N+]([O-])=O)[C@@H](C2=C([N+]([O-])=O)C=CC=C2)OC3=CC=CC=C3C1=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Pechalrieu D, et al. Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells. Eur J Med Chem. 2020 Jan 15;186:111829. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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DNMT-IN-1

DNA Methyltransferase アイソフォーム固有の製品をすべて表示