DS69910557
Based on 1 Customer Validation
DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.86%
- CAS 番号: 3032750-17-4
- 分子式: C32H33Cl2FN4O3
- 分子量:611.53
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: 0.08 μM (PTHR1)[1].
DS69910557 (compound 19e) has highly potent antagonistic activity for PTHR1 with an IC50 value of 0.08 μM[1].
DS69910557 (3 μM) exhibits excellent selectivity against human ether-a-go-go-related-gene (hERG) channel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:5mg/kg
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Administration:PO
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Result:Showed excellent PK profile, high maximum plasma concentration and plasma exposure in rats.
化学情報
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CAS 番号 3032750-17-4
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性状 Solid
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分子量 611.53
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分子式 C32H33Cl2FN4O3
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Color Off-white to light yellow
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SMILES
ClC(C=N1)=CC(C2=C(C=C(Cl)C=C2)N3C4=CC=C(N5CC(F)(CN[C@@H]6CC[C@@H](C(O)=O)CC6)C5)C=C4)=C1C(C)(C)C3=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (163.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6352 mL | 8.1762 mL | 16.3524 mL | 40.8811 mL |
| 5 mM | 0.3270 mL | 1.6352 mL | 3.2705 mL | 8.1762 mL | |
| 10 mM | 0.1635 mL | 0.8176 mL | 1.6352 mL | 4.0881 mL | |
| 15 mM | 0.1090 mL | 0.5451 mL | 1.0902 mL | 2.7254 mL | |
| 20 mM | 0.0818 mL | 0.4088 mL | 0.8176 mL | 2.0441 mL | |
| 25 mM | 0.0654 mL | 0.3270 mL | 0.6541 mL | 1.6352 mL | |
| 30 mM | 0.0545 mL | 0.2725 mL | 0.5451 mL | 1.3627 mL | |
| 40 mM | 0.0409 mL | 0.2044 mL | 0.4088 mL | 1.0220 mL | |
| 50 mM | 0.0327 mL | 0.1635 mL | 0.3270 mL | 0.8176 mL | |
| 60 mM | 0.0273 mL | 0.1363 mL | 0.2725 mL | 0.6814 mL | |
| 80 mM | 0.0204 mL | 0.1022 mL | 0.2044 mL | 0.5110 mL | |
| 100 mM | 0.0164 mL | 0.0818 mL | 0.1635 mL | 0.4088 mL |
DS69910557 関連分類
HY-148350 関連分類
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