DU172
DU172 is a ligand for the adenosine A1 receptor (Adenosine A1 Receptor), with an IC50 of 24.9 nM against A1AR and an IC50 of 0.42 μM against A2AAR.
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- CAS 番号: 321907-03-3
- 分子式: C24H30FN5O5S
- 分子量:519.59
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Adenosine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
DU172 (Compound 23a) potently binds to the A1 adenosine receptor on the cell membrane of DDT1 MF-2, with an IC50 of 24.9 nM for inhibiting [3H]DPCPX binding[2].
DU172 binds to the A2A adenosine receptor on the membrane of PC-12 cells, with an IC50 of 0.42 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 321907-03-3
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分子量 519.59
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分子式 C24H30FN5O5S
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SMILES
O=C(NCCCN1C(=O)N(C(=O)C=2NC(=NC21)C3CCCCC3)CCC)C4=CC=C(C=C4)S(=O)(=O)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Glukhova A, et al. Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity. Cell. 2017;168(5):867-877.e13. [Content Brief]
[2]. Beauglehole AR, et al. Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor. J Med Chem. 2000;43(26):4973-4980. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DU172 関連分類
HY-165509 関連分類
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