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製品番号: HY-N8541

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Endocrocin

Name: Endocrocin
Brand: MedChemExpress
SKU: HY-N8541
Price: 870.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Endocrocin is an anthraquinone fungal secondary metabolite. Endocrocin inhibits the recruitment and migration of neutrophils, and enhances the pathogenicity and virulence of Fumagillin (HY-B0751) in Drosophila. Endocrocin can be used in research related to invasive aspergillosis, viral infections and liver diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 481-70-9
分子式: C₁₆H₁₀O₇
分子量:314.25

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

Endocrocin 構造式

CAS 番号: 481-70-9

容量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

体外実験

Endocrocin (10 nM-10 μM; 45 min) inhibits the chemotaxis of human primary neutrophils toward fMLP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Endocrocin (10 μM; bath incubation; 1 hour pre-treatment) significantly reduces leukotriene B₄-induced neutrophil recruitment to the caudal fin of zebrafish larvae, and shows no lethality at concentrations up to 10 μM within 4 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

3 days post-fertilization larvae^[1]
Dosage:

10 μM
Administration:

bath incubation; 1 hour pre-treatment
Result:

Reduced the number of neutrophils recruited to the ventral fin compared to DMSO control.
Showed no reduction in zebrafish survival after 4 days at concentrations up to 10 μM.

化学情報

CAS 番号 481-70-9
分子量 314.25
分子式 C₁₆H₁₀O₇
SMILES

O=C(C(C(O)=C1C2=O)=C(C)C=C1C(C3=C2C(O)=CC(O)=C3)=O)O
Structure Classification
- Quinones
Initial Source
- Microorganisms
Aspergillus fumigatus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Berthier E, et al. Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS pathogens. 2013;9(4):e1003289. [Content Brief]

[2]. Lim FY, et al. Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus. Applied and environmental microbiology. 2012 Jun;78(12):4117-25. [Content Brief]

[3]. Sun L, et al. Metabolic engineering of Saccharomyces cerevisiae for efficient production of endocrocin and emodin. Metabolic engineering. 2019 Jul;54:212-221.

[4]. Throckmorton K, et al. Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus. Environmental microbiology. 2016 Jan;18(1):246-59. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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