Epothilone C
Epothilone C is a polyketide natural product. Epothilone C is produced by the combined action of one nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS) modules in a multienzyme system. Epothilone C can be used for tumor research.
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- 純度: 98.53%
- CAS 番号: 186692-73-9
- 分子式: C26H39NO5S
- 分子量:477.66
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L929 | IC50 |
100 ng/mL
Compound: 17
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Compound was tested for cytotoxicity against L929 fibroblast cell lines in mouse
Compound was tested for cytotoxicity against L929 fibroblast cell lines in mouse
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[PMID: 9873670] |
| L929 | IC50 |
60 ng/mL
Compound: 14
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Cytotoxicity against mouse L929 cells
Cytotoxicity against mouse L929 cells
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[PMID: 11473410] |
| MCF7 | IC50 |
97 nM
Compound: 3
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Cytotoxicity against human MCF7 cells after 3 days by SRB assay
Cytotoxicity against human MCF7 cells after 3 days by SRB assay
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[PMID: 14575429] |
| NCI-H460 | IC50 |
280 nM
Compound: 3
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Cytotoxicity against human NCI-H460 cells after 3 days by SRB assay
Cytotoxicity against human NCI-H460 cells after 3 days by SRB assay
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[PMID: 14575429] |
| SF-268 | IC50 |
340 nM
Compound: 3
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Cytotoxicity against human SF268 cells after 3 days by SRB assay
Cytotoxicity against human SF268 cells after 3 days by SRB assay
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[PMID: 14575429] |
化学情報
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CAS 番号 186692-73-9
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性状 Solid
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分子量 477.66
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分子式 C26H39NO5S
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SMILES
O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C/C=C\CCC[C@H](C)[C@H](O)[C@@H](C)C1=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
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- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Chen H, et al. Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. Chem Biol. 2001 Sep;8(9):899-912. [Content Brief]
[2]. Mutka SC, et al. Heterologous production of epothilone C and D in Escherichia coli. Biochemistry. 2006 Jan 31;45(4):1321-30. [Content Brief]
[3]. Boddy CN, et al. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. J Am Chem Soc. 2003 Mar 26;125(12):3428-9. Boddy CN, et al. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. J Am Chem Soc. 2003 Mar 26;125(12):3428-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Epothilone C 関連分類
HY-100710 関連分類
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