ER 50891
Based on 1 Customer Validation
ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.59%
- CAS 番号: 187400-85-7
- 分子式: C29H24N2O2
- 分子量:432.51
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Metabolism/Protease Compound Library
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Transcription Factor-Targeted Library
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Protein-protein Interaction Inhibitor Library
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Nuclear Receptor Compound Library
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Osteogenesis Compound Library
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Heterocyclic Compound Library
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Metabolic Enzyme Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
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RXR α |
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Cell Line
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Type | Value | Description | References |
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| HL-60 | IC50 |
6.4 nM
Compound: 12f
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Antagonistic activity was evaluated in terms of inhibition of HL-60 cell differentiation activity by ATRA (10 nM)
Antagonistic activity was evaluated in terms of inhibition of HL-60 cell differentiation activity by ATRA (10 nM)
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[PMID: 11354380] |
ER 50891 (1-3 μM, 3 days) significantly promotes total cell metabolic activity of MC3T3-E1 preosteoblasts alone and antagonizes the inhibitory effect of ATRA on total cell metabolic activity[1].
ER 50891 (0.25-3 μM, 3 days) dose-dependently relieves the inhibition of 1 μM ATRA on OCN expression in MC3T3-E1 preosteoblasts[1].
ER 50891 (1.5-3 μM, 19 days) rescues the extracellular matrix mineralization of MC3T3-E1 preosteoblasts inhibited by ATRA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 187400-85-7
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性状 Solid
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分子量 432.51
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分子式 C29H24N2O2
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Color Light yellow to yellow
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SMILES
O=C(O)C1=CC=C(C2=CC=C(C3=NC4=C(C(C)C)C=CC=C4C(C5=CC=CC=C5)=C3)N2)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ER 50891 関連分類
HY-108531 関連分類
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