Ethonafide
Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 160554-87-0
- 分子式: C22H22N2O3
- 分子量:362.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.9 nM
Compound: 24
|
Tested against A549 lung carcinoma in the sulforhodamine B assay.
Tested against A549 lung carcinoma in the sulforhodamine B assay.
|
[PMID: 8648600] |
| L1210 | IC50 |
6.7 nM
Compound: 24
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Inhibitory activity against resistant murine leukemia L1210 cell lines.
Inhibitory activity against resistant murine leukemia L1210 cell lines.
|
[PMID: 8648600] |
| L1210 | IC50 |
8 nM
Compound: 24
|
Inhibitory activity against sensitive L1210 cell lines
Inhibitory activity against sensitive L1210 cell lines
|
[PMID: 8648600] |
| L1210 | IC50 |
9.3 nM
Compound: 24
|
An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.
An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.
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[PMID: 8648600] |
| MCF7 | IC50 |
11 nM
Compound: 24
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Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
|
[PMID: 8648600] |
| MCF7 | IC50 |
14 nM
Compound: 24
|
Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.
Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.
|
[PMID: 8648600] |
| MCF7 | IC50 |
18 nM
Compound: 24
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Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.
Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.
|
[PMID: 8648600] |
| OVCAR-3 | IC50 |
0.8 nM
Compound: 24
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Inhibitory activity against OVCAR-3 cell line
Inhibitory activity against OVCAR-3 cell line
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[PMID: 8648600] |
| UACC-375 | IC50 |
19 nM
Compound: 24
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Inhibitory activity against AUC375 cell line
Inhibitory activity against AUC375 cell line
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[PMID: 8648600] |
| WiDr | IC50 |
17 nM
Compound: 24
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Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
|
[PMID: 8648600] |
| WiDr | IC50 |
63 nM
Compound: 24
|
Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.
Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.
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[PMID: 8648600] |
化学情報
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CAS 番号 160554-87-0
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分子量 362.42
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分子式 C22H22N2O3
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SMILES
O=C1N(CCN(C)C)C(C2=CC=C(OCC)C3=CC4=CC=CC=C4C1=C23)=O
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別名
AMP-53; 6-Ethoxyazonafide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Alan Pourpak, et al. Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells. J Pharmacol Exp Ther. 2007 Jun;321(3):1109-17. [Content Brief]
[2]. S M Sami, et al. 6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships. J Med Chem. 1996 Apr 12;39(8):1609-18. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ethonafide 関連分類
HY-117543 関連分類
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