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United States

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製品番号: HY-W019824

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Farnesylacetone

Farnesylacetone acts as a transcriptional regulator, RNA synthesis modulator, and male hormone. Farnesylacetone can be extracted from the androgenic glands of the green crab (Carcinus maenas). Farnesylacetone modulates transcriptional processes, inhibits uridine incorporation into all types of RNA and leucine incorporation into ovaries, while stimulating uridine incorporation into tRNA/poly (A)⁺ RNA and leucine incorporation into testes. It suppresses electron transport in mitochondrial Complex I and Complex II. Farnesylacetone inhibits vitellogenesis in crustacean ovaries and stimulates uridine incorporation in crustacean intestines. It functions as an androgen in crustaceans.

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CAS 番号: 762-29-8
分子式: C₁₈H₃₀O
分子量:262.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Farnesylacetone 構造式

CAS 番号: 762-29-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

Protein/Amino Acid MetabolismNucleotide MetabolismMitochondrial FunctionMitochondrial Oxidative Phosphorylation

Protein/Amino Acid Metabolism

Nucleotide Metabolism

Farnesylacetone (100 nM; 1-3 h) inhibits protein and RNA synthesis in immature and mature ovaries of Carcinus maenas, promotes protein and RNA synthesis in testes of Carcinus maenas, and exerts its effects at the transcriptional level rather than directly acting on the translation process^[1].

Nucleotide Metabolism

Farnesylacetone (20 ng/mL; 3 h) stimulates RNA synthesis in the intestine of Carcinus maenas (shore crab), and exhibits organ specificity, as it only inhibits RNA synthesis in the ovary^[1].

Mitochondrial Function

Mitochondrial Oxidative Phosphorylation

Farnesylacetone (228 μM) inhibits electron transfer through Complex I (NADH ubiquinone reductase) and Complex II (succinate ubiquinone reductase) in isolated rat liver mitochondria, but does not inhibit electron transfer through Complex IV (cytochrome c oxidase); among these, succinate-driven electron transfer is more sensitive to it than NADH-driven electron transfer^[2].
Farnesylacetone (228-380 μM) specifically inhibits electron transfer between succinate dehydrogenase within Complex II and the ubiquinone pool in isolated rat liver mitochondria, with no inhibitory effect on succinate dehydrogenase itself; 380 μM Farnesylacetone reduces Complex II activity by 68.5% while increasing succinate dehydrogenase activity by 8%^[2].

Mitochondrial Oxidative Phosphorylation

Farnesylacetone (1 mM) neither inhibits the oxidation of DQH₂ nor the reduction of DQ in a cell-free system; instead, it stimulates electron transfer from the NADH + DQ conjugate to cytochrome c^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Endocrine Diseases

化学情報

CAS 番号 762-29-8
分子量 262.44
分子式 C₁₈H₃₀O
SMILES

O=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Animal
Crustacea
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Berreur-Bonnenfant J, et al. Comparative effect of farnesylacetone on macromolecular synthesis in gonads of crustaceans. General and comparative endocrinology. 1984 Jun;54(3):462-8. [Content Brief]

[2]. Dupont J, et al. Farnesylacetone, a sesquiterpenic hormone of Crustacea, inhibits electron transport in isolated rat liver mitochondria. Biology of the cell. 1989;67(2):141-6. [Content Brief]

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100 mg

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