Fulzerasib
Based on 1 Customer Validation
Fulzerasib (GFH925) is an irreversible KRAS G12C inhibitor, has a synergistic anti-cancer effect with cetuximab (HY-P9905)..
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.60%
- CAS 番号: 2641747-54-6
- 分子式: C32H30ClFN6O4
- 分子量:617.07
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
KRAS(G12C) |
Fulzerasib covalently inhibits GDP/GTP nucleotide exchange on KRAS G12C (IC50: 29 nM), locking KRAS in its inactive GDP-bound state (RAS-GTP IC50: 74 nM), thereby blocking the KRAS signaling pathway (pERK IC50: 37 nM)[1].
Fulzerasib inhibits the growth of tumor cell lines carrying the KRAS G12C mutation (IC50: 2-20 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
-
CAS 番号 2641747-54-6
-
性状 Solid
-
分子量 617.07
-
分子式 C32H30ClFN6O4
-
Color Light yellow to yellow
-
SMILES
O=C(C=C)N1CCN2C(C3=C(N4C5=C(C(C)C)N=CC=C5C)N=C(C6=C(O)C=CC=C6F)C(Cl)=C3)=C(N(C)C([C@@]2([H])C1)=O)C4=O
-
別名
IBI351; GFH925
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 116.67 mg/mL (189.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (279 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6206 mL | 8.1028 mL | 16.2056 mL | 40.5140 mL |
| 5 mM | 0.3241 mL | 1.6206 mL | 3.2411 mL | 8.1028 mL | |
| 10 mM | 0.1621 mL | 0.8103 mL | 1.6206 mL | 4.0514 mL | |
| 15 mM | 0.1080 mL | 0.5402 mL | 1.0804 mL | 2.7009 mL | |
| 20 mM | 0.0810 mL | 0.4051 mL | 0.8103 mL | 2.0257 mL | |
| 25 mM | 0.0648 mL | 0.3241 mL | 0.6482 mL | 1.6206 mL | |
| 30 mM | 0.0540 mL | 0.2701 mL | 0.5402 mL | 1.3505 mL | |
| 40 mM | 0.0405 mL | 0.2026 mL | 0.4051 mL | 1.0129 mL | |
| 50 mM | 0.0324 mL | 0.1621 mL | 0.3241 mL | 0.8103 mL | |
| 60 mM | 0.0270 mL | 0.1350 mL | 0.2701 mL | 0.6752 mL | |
| 80 mM | 0.0203 mL | 0.1013 mL | 0.2026 mL | 0.5064 mL | |
| 100 mM | 0.0162 mL | 0.0810 mL | 0.1621 mL | 0.4051 mL |
Fulzerasib 関連分類
HY-152848 関連分類
Powered by Bioz