Gallamine
Gallamine is an allosteric, selective muscarinic M2 acetylcholine receptor antagonist (EC50: 130 nM for [3H]NMS dissociation from porcine muscarinic M2 receptors). Gallamine is also an acetylcholinesterase inhibitor (IC50s : 1070 μM, 1480 μM, 235 μM for EeAChE, hAChE, hBChE, respectively (in the absence of MeCN)). Gallamine increases free norepinephrine levels. Gallamine can be used as a muscle relaxant.
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- CAS 番号: 153-76-4
- 分子式: C24H45N3O3
- 分子量:423.63
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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mAChR2 130 nM (EC50) |
EeAChE 1070 μM (IC50) |
hAChE 1480 μM (IC50) |
化学情報
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CAS 番号 153-76-4
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分子量 423.63
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分子式 C24H45N3O3
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SMILES
CCN(CC)CCOC1=C(OCCN(CC)CC)C(OCCN(CC)CC)=CC=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Elsinghorst PW, et al. First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor. J Med Chem. 2007 Nov 15;50(23):5685-95. [Content Brief]
[2]. Matsuki A, et al. Effect of gallamine on plasma cortisol and catecholamine levels in man. Can Anaesth Soc J. 1973 Jul;20(4):539-45. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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