STIP1 - stress induced phosphoprotein 1 Gene

Also Known as HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10963

About STIP1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,185,272-64,204,543 (from NCBI)

This gene has 12 transcripts (splice variants), 210 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 66.9), adrenal (RPKM 34.3) and 25 other tissues.

Summary

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

STIP1 Products (3)

mRNA Protein Name
NM_001282652.2 NP_001269581.1 stress-induced-phosphoprotein 1 isoform a
NM_001282653.2 NP_001269582.1 stress-induced-phosphoprotein 1 isoform c
NM_006819.3 NP_006810.1 stress-induced-phosphoprotein 1 isoform b

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables Hsp90 protein binding IPI
IPI: Inferred from physical interaction
29127155 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20029029 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of protein folding chaperone complex IDA
IDA: Inferred from direct assay
29127155 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23349634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STIP1 Protein Structure

TPR_11

TPR_11: TPR repeat (5 - 60)

TPR_1

TPR_1: Tetratricopeptide repeat (73 - 105)

TPR_11

TPR_11: TPR repeat (224 - 287)

TPR_1

TPR_1: Tetratricopeptide repeat (300 - 328)

TPR_11

TPR_11: TPR repeat (359 - 425)

TPR_1

TPR_1: Tetratricopeptide repeat (429 - 460)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 543 a.a.
Protein Preferred Names Protein Names

stress-induced-phosphoprotein 1

  • Hsp70/Hsp90-organizing protein

STIP1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
STIP1 P31948 C3orf36 Homo sapiens Q3SXR2
Y2H Array
32814053
Intra
STIP1 P31948 C3orf36 Homo sapiens Q3SXR2
Validated Y2H
32814053
Intra
STIP1 P31948 C3orf36 Homo sapiens Q3SXR2
Y2H Pooling
32814053
Intra
STIP1 P31948 CDC37L1 Homo sapiens Q7L3B6
Lumier
25036637
Intra
STIP1 P31948 EGFR Homo sapiens P00533
Ub Reconstruction
20029029
Intra
STIP1 P31948 CCDC117 Homo sapiens Q8IWD4
Anti Tag CoIP
33961781
Intra
STIP1 P31948 CCDC117 Homo sapiens Q8IWD4
Anti Tag CoIP
35271311
Intra
STIP1 P31948 CCDC117 Homo sapiens Q8IWD4
Anti Tag CoIP
25036637
Intra
STIP1 P31948 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
28514442
Intra
STIP1 P31948 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
35271311
Intra
STIP1 P31948 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
25036637
Intra
STIP1 P31948 SPRY4 Homo sapiens Q9C004
Validated Y2H
32814053
Intra
STIP1 P31948 SPRY4 Homo sapiens Q9C004
Y2H Array
32814053
Intra
STIP1 P31948 SPRY4 Homo sapiens Q9C004
Y2H Pooling
32814053
Intra
STIP1 P31948 CDS2 Homo sapiens O95674
Validated Y2H
32814053
Intra
STIP1 P31948 CDS2 Homo sapiens O95674
Y2H Pooling
32814053
Intra
STIP1 P31948 CDS2 Homo sapiens O95674
Y2H Array
32814053
Intra
STIP1 P31948 MYC Homo sapiens P01106
Y2H Pooling
32814053
Intra
STIP1 P31948 MYC Homo sapiens P01106
Validated Y2H
32814053
Intra
STIP1 P31948 MYC Homo sapiens P01106
Y2H Array
32814053
Intra
STIP1 P31948 FOXD4L6 Homo sapiens Q3SYB3
Y2H Array
32814053
Intra
STIP1 P31948 FOXD4L6 Homo sapiens Q3SYB3
Validated Y2H
32814053
Intra
STIP1 P31948 FOXD4L6 Homo sapiens Q3SYB3
Y2H Pooling
32814053
Intra
STIP1 P31948 POLA2 Homo sapiens Q14181
Validated Y2H
32814053
Intra
STIP1 P31948 POLA2 Homo sapiens Q14181
Y2H Array
32814053
Intra
STIP1 P31948 POLA2 Homo sapiens Q14181
Y2H Pooling
32814053
Intra
STIP1 P31948 ACD Homo sapiens Q96AP0
Pull Down
21044950
Intra
STIP1 P31948 FAM9A Homo sapiens Q8IZU1
Validated Y2H
32814053
Intra
STIP1 P31948 FAM9A Homo sapiens Q8IZU1
Y2H Array
32814053
Intra
STIP1 P31948 FAM9A Homo sapiens Q8IZU1
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

STIP1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P82335 STIP1 Antibody (YA2080) WB, IHC-P, IP Human, Mouse, Rat
HY-P82335A STIP1 Antibody (YA2080)(PBS only) WB, IHC-P, IP Human, Mouse, Rat

関連疾患

Diseases Alias
Microcephaly 7, Primary, Autosomal Recessive

  • MCPH7

  • Primary Autosomal Recessive Microcephaly 7

  • Microcephaly, Primary Autosomal Recessive, 7
Retinitis Pigmentosa 61

  • RP61

  • Retinitis Pigmentosa, Type 61
Chronic Wasting Disease

  • Wasting Disease, Chronic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS09170 NECAB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13919 STIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14426 TFIP11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18548 Stip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25030 Stip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus STIP1 MGD MGI:109130
Macaca mulatta STIP1 VGNC VGNC:101405
Felis catus STIP1 VGNC VGNC:81931
Rattus norvegicus STIP1 RGD RGD:621599
Canis familiaris STIP1 VGNC VGNC:46903
Others STIP1 NCBI