CRY2 - cryptochrome circadian regulator 2 Gene

Also Known as HCRY2; PHLL2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 1408

About CRY2

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,847,118-45,883,244 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 24.1), brain (RPKM 22.3) and 25 other tissues.

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

CRY2 Products (2)

mRNA	Protein	Name
NM_001127457.3	NP_001120929.1	cryptochrome-2 isoform 2
NM_021117.5	NP_066940.3	cryptochrome-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
NOT enables DNA (6-4) photolyase activity	IDA IDA: Inferred from direct assay	8909283	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	12627958	GOA
enables damaged DNA binding	IDA IDA: Inferred from direct assay	12627958	GOA
NOT enables deoxyribodipyrimidine photo-lyase activity	IDA IDA: Inferred from direct assay	8909283	GOA
enables phosphatase binding	IPI IPI: Inferred from physical interaction	9383998	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9383998	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	12627958	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12397359	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12397359	GOA
NOT involved in photoreactive repair	IDA IDA: Inferred from direct assay	12627958	GOA
acts upstream of or within regulation of sodium-dependent phosphate transport	IDA IDA: Inferred from direct assay	9753616	GOA
involved in response to light stimulus	IMP IMP: Inferred from mutant phenotype	15751956	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in extracellular region	IDA IDA: Inferred from direct assay	9753616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRY2 Protein Structure

DNA_photolyase

FAD_binding_7

0
100
200
300
400
500
614 a.a.

Protein Preferred Names	Protein Names
cryptochrome-2	cryptochrome 2 (photolyase-like)

CRY2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CRY2	Q49AN0	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	CTBP1	Homo sapiens	Q13363-2	Validated Y2H	25416956
Intra	CRY2	Q49AN0	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	32296183
Intra	CRY2	Q49AN0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CRY2	Q49AN0	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	CRY2	Q49AN0	PDE9A	Homo sapiens	O76083-2	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	PDE9A	Homo sapiens	O76083-2	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	VWC2	Homo sapiens	Q2TAL6	Y2H Array	32296183
Intra	CRY2	Q49AN0	VWC2	Homo sapiens	Q2TAL6	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP5-2	Homo sapiens	Q701N4	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP5-2	Homo sapiens	Q701N4	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP5-4	Homo sapiens	Q6L8H1	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP5-4	Homo sapiens	Q6L8H1	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP5-4	Homo sapiens	Q6L8H1	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP5-7	Homo sapiens	Q6L8G8	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP5-1	Homo sapiens	Q6L8H4	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KRTAP5-1	Homo sapiens	Q6L8H4	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP5-1	Homo sapiens	Q6L8H4	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	CRY2	Q49AN0	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	CRY2	Q49AN0	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	CRY2	Q49AN0	MID1	Homo sapiens	O15344	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	MID1	Homo sapiens	O15344	Y2H Array	32296183
Intra	CRY2	Q49AN0	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	CRY2	Q49AN0	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	CRY2	Q49AN0	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	XRN2	Homo sapiens	Q9H0D6	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	XRN2	Homo sapiens	Q9H0D6	Y2H Array	32296183
Intra	CRY2	Q49AN0	XRN2	Homo sapiens	Q9H0D6	Validated Y2H	32296183
Intra	CRY2	Q49AN0	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CRY2	Q49AN0	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	KLHL6	Homo sapiens	Q8WZ60	Validated Y2H	32296183
Intra	CRY2	Q49AN0	KLHL6	Homo sapiens	Q8WZ60	Y2H Array	32296183
Intra	CRY2	Q49AN0	KLHL6	Homo sapiens	Q8WZ60	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	PPP5C	Homo sapiens	P53041	Anti Tag CoIP	16790549
Intra	CRY2	Q49AN0	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	CRY2	Q49AN0	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	CRY2	Q49AN0	PDE9A	Homo sapiens	O76083	Y2H Array	25416956
Intra	CRY2	Q49AN0	PDE9A	Homo sapiens	O76083	Y2H Prey Pooling	25416956
Intra	CRY2	Q49AN0	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	CRY2	Q49AN0	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	CRY2	Q49AN0	NADK	Homo sapiens	O95544	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	NADK	Homo sapiens	O95544	Y2H Array	32296183
Intra	CRY2	Q49AN0	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	CRY2	Q49AN0	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	CRY2	Q49AN0	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	CRY2	Q49AN0	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	CRY2	Q49AN0	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	CRY2	Q49AN0	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Advanced Sleep Phase Syndrome	Fasps Familial Advanced Sleep-Phase Syndrome Advanced Sleep Phase Syndrome, Familial Familial Advanced Sleep Phase Syndrome Sleep Phase Syndrome, Advanced, Familial Advanced Sleep-Phase Syndrome, Familial
Delayed Sleep Phase Disorder	Delayed Sleep Phase Syndrome Delayed Sleep Phase Syndrome, Susceptibility To DSPD Delayed Sleep Phase Disorder, Susceptibility To DSPS Sleep Phase, Delayed, Disorder Sleep Phase Syndrome, Delayed, Susceptibility To
Sleep Disorder	Sleep Disorders Non-Organic Sleep Disorder
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Dysthymic Disorder	Dysthymia Chronic Depressive Disorder Chronic Depression Depressive Personality Depressive Personality Disorder Persistent Depressive Disorder Persistent Depression
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-108468	KL001		99.06%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-134194	KL201		98.18%	Unkown
HY-134192	TH301		/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	CRY2	VGNC	VGNC:27731
Canis familiaris	CRY2	VGNC	VGNC:39634
Mus musculus	CRY2	MGD	MGI:1270859
Felis catus	CRY2	VGNC	VGNC:61196
Rattus norvegicus	CRY2	RGD	RGD:620935
Macaca mulatta	CRY2	VGNC	VGNC:71500
Others	CRY2	NCBI