GGW
GGW is a tripeptide with neuroprotective activity. GGW blocks the mitochondria-mediated apoptosis pathway, reverses glutamate-induced upregulation of the pro-apoptotic protein Bax and downregulation of the anti-apoptotic protein Bcl-2. GGW reduces ROS production, reverses the depletion of SOD and Glutathione Peroxidase, decreases intracellular calcium concentration, and reverses the collapse of mitochondrial membrane potential. GGW can be used in studies related to memory impairment induced by sleep deprivation.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 20762-32-7
- 分子式: C15H18N4O4
- 分子量:318.33
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
Bax |
Bcl-2 |
体外実験
GGW (0.10 mM; 24 h) protects PC12 cells from glutamate-induced cytotoxicity and restores cell viability to 78.29% of that in the control group[1].
GGW (0.10 mM) exhibits free radical scavenging activity in cell-free ABTS assays[1].
GGW (0.10 mM; 24 h) reverses the glutamate-induced decreases in SOD and GSH-px activities and increase in MDA content in PC12 cells; it reduces ROS accumulation, inhibits LDH leakage, and alleviates cell damage; it suppresses Ca2+ influx and reduces intracellular calcium concentration to 250.65 mmol/L; it reverses mitochondrial membrane potential collapse and restores MMP to 90.17% of the control group level[1].
GGW (0.10 mM; 24 h) regulates the expression of apoptosis-related proteins Bax and Bcl-2 in glutamate-treated PC12 cells, reducing the Bax/Bcl-2 ratio to 107.04% of that in the control group[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:rat pheochromocytoma PC12 cells (glutamate-induced cytotoxicity)
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Concentration:0.10 mM
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Incubation Time:24 h
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Result:Restored PC12 cell viability to 78.29% of the control value.
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Cell Line:glutamate-injured PC12 cells
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Concentration:0.10 mM
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Incubation Time:24 h
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Result:Down-regulated Bax expression.
Up-regulated Bcl-2 expression.
Reduced the Bax/Bcl-2 ratio to 107.04% of the control value.
化学情報
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CAS 番号 20762-32-7
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分子量 318.33
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分子式 C15H18N4O4
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SMILES
NCC(NCC(N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GGW 関連分類
HY-187115 関連分類
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