GMQ
Based on 1 publication(s) in Google Scholar
GMQ (hydrochloride) is a ASIC (acid-sensing ion) channel activator with an EC50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ (hydrochloride) opens only ASIC3 but no other ASICs at pH 7.4. GMQ (hydrochloride) can be used for neurological disease research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.86%
- CAS 番号: 5361-15-9
- 分子式: C10H12ClN5
- 分子量:237.69
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 GMQ hydrochloride
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生物活性
GMQ (hydrochloride) (1 mM) generates a sustained inward current at pH 7.4 in CHO cells[1]. GMQ (hydrochloride) blocks ASIC pore at high concentrations with IC50 values of 3.24, 1.52 and 6.74 mM for ASIC1a, ASIC1b and ASIC3, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 5361-15-9
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性状 Solid
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分子量 237.69
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分子式 C10H12ClN5
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Color White to off-white
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SMILES
CC1=NC(NC(N)=N)=NC2=CC=CC=C12.Cl
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別名
2-Guanidine-4-methylquinazoline hydrochloride
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur J Pharmacol
2-guanidine-4-methylquinazoline inhibits platelet activation and thrombosis by targeting the acid-sensing ion channel 3. [Abstract]2026 May 30:1030:179005. PMID: 42219052
溶剤 & 溶解度
H2O : 10 mg/mL (42.07 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.2072 mL | 21.0358 mL | 42.0716 mL | 105.1790 mL |
| 5 mM | 0.8414 mL | 4.2072 mL | 8.4143 mL | 21.0358 mL | |
| 10 mM | 0.4207 mL | 2.1036 mL | 4.2072 mL | 10.5179 mL | |
| 15 mM | 0.2805 mL | 1.4024 mL | 2.8048 mL | 7.0119 mL | |
| 20 mM | 0.2104 mL | 1.0518 mL | 2.1036 mL | 5.2590 mL | |
| 25 mM | 0.1683 mL | 0.8414 mL | 1.6829 mL | 4.2072 mL | |
| 30 mM | 0.1402 mL | 0.7012 mL | 1.4024 mL | 3.5060 mL | |
| 40 mM | 0.1052 mL | 0.5259 mL | 1.0518 mL | 2.6295 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
GMQ hydrochloride 関連分類
HY-107757 関連分類
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