Gomisin M1
Based on 1 Customer Validation
Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC50 of <0.65 μM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.75%
- CAS 番号: 82467-50-3
- 分子式: C22H26O6
- 分子量:386.44
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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HIV-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human A549 cells after 3 days by MTT assay
Cytotoxicity against human A549 cells after 3 days by MTT assay
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[PMID: 23738539] |
| H9 | EC50 |
<0.65 μM
Compound: 4
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Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA
Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA
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[PMID: 17190445] |
| H9 | IC50 |
44.5 μM
Compound: 4
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Cytotoxicity against human H9 cells after 4 days
Cytotoxicity against human H9 cells after 4 days
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[PMID: 17190445] |
| HCT-116 | IC50 |
55.38 μM
Compound: GM
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Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| HeLa | IC50 |
17.15 μM
Compound: GM
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Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay
Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay
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[PMID: 34038111] |
| HeLa | IC50 |
32.83 μM
Compound: GM
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Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| HepG2 | IC50 |
27.26 μM
Compound: GM
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Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| Huh-7 | IC50 |
32.23 μM
Compound: GM
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Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| MCF7 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
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[PMID: 23738539] |
| MDA-MB-231 | IC50 |
56.61 μM
Compound: GM
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Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| MHCC97 | IC50 |
24.75 μM
Compound: GM
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Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
| NB-4 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human NB4 cells after 3 days by MTT assay
Cytotoxicity against human NB4 cells after 3 days by MTT assay
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[PMID: 23738539] |
| PC-3 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human PC3 cells after 3 days by MTT assay
Cytotoxicity against human PC3 cells after 3 days by MTT assay
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[PMID: 23738539] |
| SH-SY5Y | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay
Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay
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[PMID: 23738539] |
| SK-HEP1 | IC50 |
20.56 μM
Compound: GM
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Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay
Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay
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[PMID: 34038111] |
Gomisin M1 ((±)-Gomisin M1) (4 days) shows anti-HIV-1 activity with an EC50 of <0.65 μM in H9 T cell lines and therapeutic index (TI) is >68[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 82467-50-3
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性状 Solid
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分子量 386.44
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分子式 C22H26O6
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Color White to off-white
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SMILES
OC1=C(C2=C3C=C4OCOC4=C2OC)C(CC(C)C(C)C3)=CC(OC)=C1OC
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別名
(±)-Gomisin M1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 17.2 mg/mL (44.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5877 mL | 12.9386 mL | 25.8772 mL | 64.6931 mL |
| 5 mM | 0.5175 mL | 2.5877 mL | 5.1754 mL | 12.9386 mL | |
| 10 mM | 0.2588 mL | 1.2939 mL | 2.5877 mL | 6.4693 mL | |
| 15 mM | 0.1725 mL | 0.8626 mL | 1.7251 mL | 4.3129 mL | |
| 20 mM | 0.1294 mL | 0.6469 mL | 1.2939 mL | 3.2347 mL | |
| 25 mM | 0.1035 mL | 0.5175 mL | 1.0351 mL | 2.5877 mL | |
| 30 mM | 0.0863 mL | 0.4313 mL | 0.8626 mL | 2.1564 mL | |
| 40 mM | 0.0647 mL | 0.3235 mL | 0.6469 mL | 1.6173 mL |
Gomisin M1 関連分類
HY-N1529 関連分類
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