製品番号: HY-N3980

Guaiol

(別名: Champacol; Guaiac alcohol; グアイオール)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC₅₀ of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions^[4]

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.67%
CAS 番号: 489-86-1
分子式: C₁₅H₂₆O
分子量:222.37

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Guaiol 構造式

CAS 番号: 489-86-1

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Guaiol (150 μM, 24 h) has an inhibitory effect on non-small cell lung cancer (NSCLC) cell lines (A549 cells and H1299 cells)^[1].
Guaiol (0.1-50 μg/ml, 24 h) inhibits the growth of parasites in thioglycolate (HY-W115724)-stimulated macrophages from BALB/c mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

A549 cells, H1299 cells
Concentration:

150 μM
Incubation Time:

24 h
Result:

Dramatically inhibited cell growth of A549 cells and H1299 cells with IC₅₀ values 121.7 μM and 211.5 μM.

Cell Cytotoxicity Assay^[5]

Cell Line:

Thioglycolate (HY-W115724)-stimulated macrophages from BALB/c mice
Concentration:

0.1-50 μg/ml
Incubation Time:

24 h
Result:

Did not inhibit the macrophage phagocytic ability.
Induced a significant decrease in the parasite survival index when compared with untreated control.

体内実験

Guaiol (8 mg/kg, i.p., 3 times a week for 40 consecutive days) exhibited anti-tumor activity in the non-small cell lung cancer (NSCLC) xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Non-small cell lung cancer (NSCLC) xenograft mouse model^[1]
Dosage:

8 mg/kg
Administration:

Intraperitoneal injection (i.p.), 3 times a week for 40 days
Result:

Reduced the tumor volume and weight in the non-small cell lung cancer (NSCLC) xenograft mouse model.

化学情報

CAS 番号 489-86-1
性状 Solid
分子量 222.37
分子式 C₁₅H₂₆O
Color White to off-white
SMILES

C[C@@H]1C2=C([C@H](CC[C@@H](C(C)(O)C)C2)C)CC1
別名

Champacol; Guaiac alcohol; グアイオール
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Plants
- Compositae
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

All

Sort by:

Journal Impact Factor

Biol Proced Online

(-)-Guaiol Downregulates M2 Tumor-Associated Macrophage Polarization Through PPAR-γ Signaling to Suppress Lung Cancer. [Abstract]

2025 Dec 5. PMID: 41350836

溶剤 & 溶解度

体外:

DMSO : 33.33 mg/mL (149.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.4970 mL

22.4850 mL

44.9701 mL

5 mM

0.8994 mL

4.4970 mL

8.9940 mL

10 mM

0.4497 mL

2.2485 mL

4.4970 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 1 mg/mL (4.50 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (281 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yang, Q, et al. (−)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer Oncotarget. 2016 Sep 20;7(38):62585-62597. [Content Brief]

[2]. Ali, A., Tabanca, et al. Chemical composition and biological activity of four salvia essential oils and individual compounds against two species of mosquitoes J. Agric. Food Chem. 63(2), 447-456 (2015). [Content Brief]

[3]. Liu, T, et al. Guaiol - a naturally occurring insecticidal sesquiterpene Nat. Prod. Commun. 8(10), 1353-1354 (2013). [Content Brief]

[4]. Garcia M C F, et al. The in vitro antileishmanial activity of essential oil from Aloysia gratissima and guaiol, its major sesquiterpene against Leishmania amazonensis[J]. Parasitology, 2018, 145(9): 1219-1227. [Content Brief]

[5]. Thurman E M. Analysis of terpenes in hemp (Cannabis sativa) by gas chromatography/mass spectrometry: Isomer identification analysis[M]//Comprehensive Analytical Chemistry. Elsevier, 2020, 90: 197-233.

[6]. Yang M, et al. Determination and pharmacokinetic study of guaiol in rat plasma by gas chromatography–mass spectrometry with selected ion monitoring[J]. Journal of Chromatography B, 2018, 1085: 30-35. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.4970 mL	22.4850 mL	44.9701 mL	112.4252 mL
	5 mM	0.8994 mL	4.4970 mL	8.9940 mL	22.4850 mL
	10 mM	0.4497 mL	2.2485 mL	4.4970 mL	11.2425 mL
	15 mM	0.2998 mL	1.4990 mL	2.9980 mL	7.4950 mL
	20 mM	0.2249 mL	1.1243 mL	2.2485 mL	5.6213 mL
	25 mM	0.1799 mL	0.8994 mL	1.7988 mL	4.4970 mL
	30 mM	0.1499 mL	0.7495 mL	1.4990 mL	3.7475 mL
	40 mM	0.1124 mL	0.5621 mL	1.1243 mL	2.8106 mL
	50 mM	0.0899 mL	0.4497 mL	0.8994 mL	2.2485 mL
	60 mM	0.0750 mL	0.3748 mL	0.7495 mL	1.8738 mL
	80 mM	0.0562 mL	0.2811 mL	0.5621 mL	1.4053 mL
	100 mM	0.0450 mL	0.2249 mL	0.4497 mL	1.1243 mL

Keywords

Guaiol

1 Cited Publications

100 mg お問い合わせ

Subscribe to the

MedChemExpress

Newsletter

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Guaiol

Anti-Infection Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Lipid Compound Library

Anti-Cardiovascular Disease Compound Library

Medicine Food Homology Compound Library

Terpenoids Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Lung Cancer Compound Library

Antiparasitic Compound library

Food-Sourced Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Protein Kinase Compound Library

RO5 Drug-like Natural Product Library

Flavor Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Mass Spectrometry Natural Product Library

MedChemExpress（MCE）の使用を引用している文献 Guaiol

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Guaiol 関連分類

HY-N3980 関連分類