H3B-968
Based on 2 publication(s) in Google Scholar
H3B-968 is the ATP-competitive inhibitor of Werner syndrome protein (WRN) with an IC50 of about 10 nM.
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- 純度 : 98.22%
- CAS 番号: 2912294-90-5
- 分子式: C22H18F6N4O4S
- 分子量:548.46
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 H3B-968
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生物活性
製品説明
IC50 & Target
Werner syndrome protein (WRN)[1]
体外実験
H3B-968 covalently binds to the C727 site on the WRN protein, causing the loss of WRN helicase activity, thereby affecting processes such as DNA replication, repair and recombination. Werner syndrome protein (WRN) acts as the helicase, ATPase, and exonuclease. WRN exhibits synthetic lethal activity in cancer research[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2912294-90-5
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性状 Solid
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分子量 548.46
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分子式 C22H18F6N4O4S
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Color White to off-white
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SMILES
O=C(CNS(=O)(C1=NC(C2=CC=C(OC(F)(F)F)C=C2)=CC(C(F)(F)F)=N1)=O)NC3=CC=C(CC)C=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
2025 Feb;12(8):e2413368. PMID: 39737862 -
溶剤 & 溶解度
体外:
DMSO : ≥ 250 mg/mL (455.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8233 mL | 9.1164 mL | 18.2329 mL | 45.5822 mL |
| 5 mM | 0.3647 mL | 1.8233 mL | 3.6466 mL | 9.1164 mL | |
| 10 mM | 0.1823 mL | 0.9116 mL | 1.8233 mL | 4.5582 mL | |
| 15 mM | 0.1216 mL | 0.6078 mL | 1.2155 mL | 3.0388 mL | |
| 20 mM | 0.0912 mL | 0.4558 mL | 0.9116 mL | 2.2791 mL | |
| 25 mM | 0.0729 mL | 0.3647 mL | 0.7293 mL | 1.8233 mL | |
| 30 mM | 0.0608 mL | 0.3039 mL | 0.6078 mL | 1.5194 mL | |
| 40 mM | 0.0456 mL | 0.2279 mL | 0.4558 mL | 1.1396 mL | |
| 50 mM | 0.0365 mL | 0.1823 mL | 0.3647 mL | 0.9116 mL | |
| 60 mM | 0.0304 mL | 0.1519 mL | 0.3039 mL | 0.7597 mL | |
| 80 mM | 0.0228 mL | 0.1140 mL | 0.2279 mL | 0.5698 mL | |
| 100 mM | 0.0182 mL | 0.0912 mL | 0.1823 mL | 0.4558 mL |
H3B-968 関連分類
HY-149887 関連分類
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