HDMAPP triammonium
Based on 1 Customer Validation
HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 90.0%
- CAS 番号: 443892-56-6
- 分子式: C5H21N3O8P2
- 分子量:313.18
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
TNFRSF1A |
体外実験
HDMAPP triammonium (compound 3E) (2 μM) increases TNF-α release levels in primary polyclonal human Vγ9Vδ2 T cells and has stimulatory bioactivity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nonhuman Primate Model in Cynomolgus[1]
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Dosage:0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg
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Administration:Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
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Result:Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 2.5 mg/kg.
化学情報
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CAS 番号 443892-56-6
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性状 Solid
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分子量 313.18
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分子式 C5H21N3O8P2
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Color White to off-white
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SMILES
OC/C(C)=C/COP(OP(O)(O)=O)(O)=O.N.N.N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
PBS : 10 mg/mL (31.93 mM; ultrasonic and warming and adjust pH to 7.2)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
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- Deutsch - DE (252 KB)
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- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| PBS | 1 mM | 3.1931 mL | 15.9653 mL | 31.9305 mL | 79.8263 mL |
| 5 mM | 0.6386 mL | 3.1931 mL | 6.3861 mL | 15.9653 mL | |
| 10 mM | 0.3193 mL | 1.5965 mL | 3.1931 mL | 7.9826 mL | |
| 15 mM | 0.2129 mL | 1.0644 mL | 2.1287 mL | 5.3218 mL | |
| 20 mM | 0.1597 mL | 0.7983 mL | 1.5965 mL | 3.9913 mL | |
| 25 mM | 0.1277 mL | 0.6386 mL | 1.2772 mL | 3.1931 mL | |
| 30 mM | 0.1064 mL | 0.5322 mL | 1.0644 mL | 2.6609 mL |
HDMAPP triammonium 関連分類
HY-145498 関連分類
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