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Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95%
- CAS 番号: 9013-72-3
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Human Endogenous Metabolite |
Hemocyanin (10-50 μg/mL; 48 h) from Litopenaeus vannamei exhibits antiproliferative activity against HeLa cells (57-71% inhibition)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells, 293T cells
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Concentration:10, 20, 30, 40, 50 μg/mL
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Incubation Time:24 h, 48 h
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Result:Inhibited HeLa cell growth by 57-71% at 10-50 μg/mL for 48 h (p < 0.01). Showed no significant growth inhibition in 293T cells under the same conditions.
化学情報
溶剤 & 溶解度
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Zheng L, et al. Hemocyanin from Shrimp Litopenaeus vannamei Has Antiproliferative Effect against HeLa Cell In Vitro. PLoS One. 2016 Mar 23;11(3):e0151801. doi: 10.1371/journal.pone.0151801. PMID: 27007573; PMCID: PMC4805270. [Content Brief]
[2]. Cheng J, et al. Hemocyanin controls Vibrio levels in hemolymph by modulating intracellular ROS via p38 MAPK. Virulence. 2025;16(1):2546066. [Content Brief]
[3]. Decker H, et al. Minireview: Recent progress in hemocyanin research. Integr Comp Biol. 2007;47(4):631-644. [Content Brief]
[4]. Antonova O, et al. In vitro antiproliferative effect of Helix aspersa hemocyanin on multiple malignant cell lines. Z Naturforsch C J Biosci. 2014;69(7-8):325-334. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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