Iobenguane (sulfate)
Based on 1 publication(s) in Google Scholar
m-Iodobenzylguanidine sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated m-Iodobenzylguanidine sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. m-Iodobenzylguanidine sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation).
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- 純度: 99.76%
- CAS 番号: 87862-25-7
- 分子式: C8H10IN3.1/2H2O4S
- 分子量:324.13
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 m-Iodobenzylguanidine sulfate
MoreAdrenergic Receptor アイソフォーム固有の製品をすべて表示
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生物活性
m-Iodobenzylguanidine sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines[1].
m-Iodobenzylguanidine sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells
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Concentration:2, 20μg/ml
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Incubation Time:72 hours
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Result:Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth.
The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of m-Iodobenzylguanidine sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed[1].
m-Iodobenzylguanidine sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/2 (L1210)) mice[1]
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Dosage:i.p.; daily on days 3-6
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Administration:20 mg/kg
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Result:Considerable prolongation of survival and some cures were obtained.
化学情報
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CAS 番号 87862-25-7
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性状 Solid
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分子量 324.13
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分子式 C8H10IN3.1/2H2O4S
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Color White to off-white
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SMILES
NC(NCC1=CC=CC(I)=C1)=N.O=S(O)(O)=O.[1/2]
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別名
MIBG (sulfate)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2024 Sep;633(8029):473-479. PMID: 39143211
溶剤 & 溶解度
DMSO : 100 mg/mL (308.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0852 mL | 15.4259 mL | 30.8518 mL | 77.1295 mL |
| 5 mM | 0.6170 mL | 3.0852 mL | 6.1704 mL | 15.4259 mL | |
| 10 mM | 0.3085 mL | 1.5426 mL | 3.0852 mL | 7.7130 mL | |
| 15 mM | 0.2057 mL | 1.0284 mL | 2.0568 mL | 5.1420 mL | |
| 20 mM | 0.1543 mL | 0.7713 mL | 1.5426 mL | 3.8565 mL | |
| 25 mM | 0.1234 mL | 0.6170 mL | 1.2341 mL | 3.0852 mL | |
| 30 mM | 0.1028 mL | 0.5142 mL | 1.0284 mL | 2.5710 mL | |
| 40 mM | 0.0771 mL | 0.3856 mL | 0.7713 mL | 1.9282 mL | |
| 50 mM | 0.0617 mL | 0.3085 mL | 0.6170 mL | 1.5426 mL | |
| 60 mM | 0.0514 mL | 0.2571 mL | 0.5142 mL | 1.2855 mL | |
| 80 mM | 0.0386 mL | 0.1928 mL | 0.3856 mL | 0.9641 mL | |
| 100 mM | 0.0309 mL | 0.1543 mL | 0.3085 mL | 0.7713 mL |
m-Iodobenzylguanidine sulfate 関連分類
HY-129040A 関連分類
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