KAI-1678
KAI-1678 is a selective protein kinase Cε (PKCε) inhibitor that competitively blocks the binding of PKCε to its anchoring protein RACK. KAI-1678 attenuates the responses of nociceptive neurons in rodent neuropathic pain models. KAI-1678 can be used in research related to moderate to severe postoperative pain, neuropathic pain, and postherpetic neuralgia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1041004-14-1
- 分子式: C107H190N44O28
- 分子量:2540.93
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
PKCε |
体外実験
KAI-1678 competitively and selectively blocks the binding of PKC epsilon to its anchoring protein RACK2, and inhibits PKC epsilon membrane translocation as well as phosphorylation of downstream pain-related substrates[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1041004-14-1
-
分子量 2540.93
-
分子式 C107H190N44O28
-
配列
Ac-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-Gly-Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
-
シーケンスの短縮
Ac-EAVSLKPTGGYGRKKRRQRRR-NH2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Cousins MJ, et al. The safety and efficacy of KAI-1678- an inhibitor of epsilon protein kinase C (εPKC)-versus lidocaine and placebo for the treatment of postherpetic neuralgia: a crossover study design. Pain medicine (Malden, Mass.). 2013 Apr;14(4):533-40. [Content Brief]
[2]. Yonezawa T, et al. PKC delta and epsilon in drug targeting and therapeutics. Recent patents on DNA & gene sequences. 2009;3(2):96-101. [Content Brief]
[3]. Leppänen T, et al. Protein kinase C and its inhibitors in the regulation of inflammation: inducible nitric oxide synthase as an example. Basic & clinical pharmacology & toxicology. 2014 Jan;114(1):37-43. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KAI-1678 関連分類
HY-P11803 関連分類
Powered by Bioz