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製品番号: HY-P11803

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KAI-1678

KAI-1678 is a selective protein kinase Cε (PKCε) inhibitor that competitively blocks the binding of PKCε to its anchoring protein RACK. KAI-1678 attenuates the responses of nociceptive neurons in rodent neuropathic pain models. KAI-1678 can be used in research related to moderate to severe postoperative pain, neuropathic pain, and postherpetic neuralgia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1041004-14-1
分子式: C₁₀₇H₁₉₀N₄₄O₂₈
分子量:2540.93

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

KAI-1678 構造式

CAS 番号: 1041004-14-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
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関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

PKCε

PKC アイソフォーム固有の製品をすべて表示 :

体外実験

KAI-1678 competitively and selectively blocks the binding of PKC epsilon to its anchoring protein RACK2, and inhibits PKC epsilon membrane translocation as well as phosphorylation of downstream pain-related substrates^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

KAI-1678 (subcutaneous infusion) exerts dose-dependent effects in rodent models including carrageenan-induced acute inflammatory pain in rats, chronic constriction injury (CCI), and L5 spinal nerve transection-induced peripheral neuropathy, and reverses inflammatory hyperalgesia and mechanical allodynia^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1041004-14-1
分子量 2540.93
分子式 C₁₀₇H₁₉₀N₄₄O₂₈
配列

Ac-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-Gly-Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
シーケンスの短縮

Ac-EAVSLKPTGGYGRKKRRQRRR-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Cousins MJ, et al. The safety and efficacy of KAI-1678- an inhibitor of epsilon protein kinase C (εPKC)-versus lidocaine and placebo for the treatment of postherpetic neuralgia: a crossover study design. Pain medicine (Malden, Mass.). 2013 Apr;14(4):533-40. [Content Brief]

[2]. Yonezawa T, et al. PKC delta and epsilon in drug targeting and therapeutics. Recent patents on DNA & gene sequences. 2009;3(2):96-101. [Content Brief]

[3]. Leppänen T, et al. Protein kinase C and its inhibitors in the regulation of inflammation: inducible nitric oxide synthase as an example. Basic & clinical pharmacology & toxicology. 2014 Jan;114(1):37-43. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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KAI-1678

PKC アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

KAI-1678 関連分類

HY-P11803 関連分類