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製品番号: HY-P2674

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KDEL

KDEL is a tetrapeptide serving as an endoplasmic reticulum (ER) retrieval/retention signal. KDEL can target and deliver exogenous antigen peptides to the ER, significantly enhance and prolong MHC class I molecule presentation, and effectively boost anti-tumor immune responses.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 113516-56-6
分子式: C₂₁H₃₇N₅O₉
分子量:503.55

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

KDEL 構造式

CAS 番号: 113516-56-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

MHC アイソフォーム固有の製品をすべて表示 :

MHC I
MHC II

体外実験

KDEL (10 μM; 30 min-10 h) fused to the C-terminus of OVA_257-264 enhances MHC class I-associated peptide presentation on EL-4 and RMA cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

KDEL (10 μM; subcutaneous injection after DC loading; twice) significantly enhances and prolongs MHC class I presentation of exogenous peptides in C57BL/6 mice, induces a stronger specific CTL response, and significantly inhibits E.G7‑OVA tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice (6-8 weeks old) with E.G7‑OVA tumor challenge^[1]
Dosage:

10 μM OVA_257‑264‑KDEL peptide
Administration:

subcutaneous injection ( days 0 and 7)
Result:

Induced greatly enhanced specific CD8⁺ cytotoxic T lymphocyte (CTL) responses, remarkably prolonged surface MHC class I/peptide complex display, and resulted in significant inhibition of E.G7‑OVA tumor growth in vivo compared with OVA_257‑264 or OVA_257‑264‑TEWT peptide groups.

化学情報

CAS 番号 113516-56-6
分子量 503.55
分子式 C₂₁H₃₇N₅O₉
配列

Lys-Asp-Glu-Leu
シーケンスの短縮

KDEL
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wang L, et al. MHC class I-associated presentation of exogenous peptides is not only enhanced but also prolonged by linking with a C-terminal Lys-Asp-Glu-Leu endoplasmic reticulum retrieval signal. Eur J Immunol. 2004;34(12):3582-3594. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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KDEL

MHC アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

KDEL 関連分類

HY-P2674 関連分類