KMUP-4
KMUP-4, as a xanthine derivative with cGMP-enhancing activity, induces aortic relaxation through endothelium-dependent and independent mechanisms. KMUP-4 increases cytoplasmic cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) levels by inhibiting phosphodiesterases (PDEs) and activating K+ channels. KMUP-4 can be used in the study of cardiovascular diseases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 864873-81-4
- 分子式: C19H23N7O4
- 分子量:413.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
KMUP-4 (1 nM-100 μM) produces concentration-dependent vasorelaxant effects on deendothelial aortas (E2) (pEC50=5.94) and intact endothelial aortas (E+) (PEC50=6.45), indicating that the vasodilatory effect of KMUP-4 is partially dependent on endothelial cells[1]. KMUP-4 (10 μM) shows 56%, 33% and 15% inhibitory activity against PDE3, PDE4 and PDE5 in HUVECs[1]. KMUP-4 (0.1 μM, 18 h) increases significantly the expression of eNOS protein in HUVECs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 864873-81-4
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分子量 413.43
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分子式 C19H23N7O4
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SMILES
O=C1C2=C(N(C(N1C)=O)C)N=CN2CCN3CCN(CC3)C4=C(C=CC=C4)[N+]([O-])=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KMUP-4 関連分類
HY-129210 関連分類
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