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製品番号: HY-149462

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KN1022

Name: KN1022
Brand: MedChemExpress
SKU: HY-149462
Price: 127.00 USD
Availability: InStock
Rating: 5 (1 reviews)

KN1022 an inhibitor of phosphorylation of platelet-derived growth factor receptor (PDGFR) with IC₅₀ of 0.24 μM.

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CAS 番号: 205255-11-4
分子式: C₂₁H₂₂N₆O₅
分子量:438.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

KN1022 構造式

CAS 番号: 205255-11-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

KN1022 an inhibitor of phosphorylation of platelet-derived growth factor receptor (PDGFR) with IC₅₀ of 0.24 μM^[1].

PDGFR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.7 μM Compound: KN1022	Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells	[PMID: 12941321]
CHO	IC₅₀	0.7 μM/L Compound: KN1022	Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells	[PMID: 12941321]
PASMC	IC₅₀	0.1 μM Compound: KN1022	Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells	[PMID: 12086491]
PASMC	IC₅₀	0.1 μM/L Compound: KN1022	Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells	[PMID: 12086491]

化学情報

CAS 番号 205255-11-4
分子量 438.44
分子式 C₂₁H₂₂N₆O₅
SMILES

O=C(N1CCN(CC1)C2=C3C=C(OC)C(OC)=CC3=NC=N2)NC4=CC=C([N+]([O-])=O)C=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kenji Matsuno, et al. Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J Med Chem. 2002 Jul 4;45(14):3057-66. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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