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製品番号: HY-123442

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L 775,606

L 775,606 is a potent and selective 5-HT1D receptor agonist. L 775,606 can be used to study migraine headache.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 188400-51-3
分子式: C₂₅H₂₉FN₆
分子量:432.54

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

L 775,606 構造式

CAS 番号: 188400-51-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

L 775,606 is a potent and selective 5-HT1D receptor agonist. L 775,606 can be used to study migraine headache^[1].

IC₅₀ & Target

5-HT_1D Receptor

5-HT Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	1 nM Compound: 3	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor	[PMID: 10377215]
CHO	EC₅₀	1 nM Compound: 7f	Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor. Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.	[PMID: 10052976]
CHO	EC₅₀	1.2 nM Compound: 15	Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor. Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.	[PMID: 9357515]
CHO	EC₅₀	1.2 nM Compound: 4	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	[PMID: 9667955]
CHO	EC₅₀	430 nM Compound: 3	Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor	[PMID: 10377215]
CHO	IC₅₀	0.5 nM Compound: 3	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells	[PMID: 10377215]
CHO	IC₅₀	0.5 nM Compound: 7f	Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	[PMID: 10052976]
CHO	IC₅₀	0.6 nM Compound: 15	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	[PMID: 9357515]
CHO	IC₅₀	0.6 nM Compound: 4	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	[PMID: 9667955]
CHO	IC₅₀	72 nM Compound: 3	Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells	[PMID: 10377215]
CHO	IC₅₀	72 nM Compound: 7f	Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells. Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.	[PMID: 10052976]
CHO	IC₅₀	75 nM Compound: 15	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells	[PMID: 9357515]
CHO-K1	IC₅₀	0.6 nM Compound: L-775606	Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting	[PMID: 18507369]

化学情報

CAS 番号 188400-51-3
分子量 432.54
分子式 C₂₅H₂₉FN₆
SMILES

FC1=CC(CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)=CC=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Prueksaritanont T, et al. Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist. Xenobiotica. 2000 Jan;30(1):47-59. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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L 775,606

5-HT Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

L 775,606 関連分類

HY-123442 関連分類