Lactoferrin
Based on 1 Customer Validation
Lactoferrin from Bovine milk is a substance released by neutrophils. Lactoferrin from Bovine milk is an orally active multifunctional iron binding glycoprotein. Lactoferrin from Bovine milk prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin from Bovine milk also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin from Bovine milk has anti-inflammatory, immunomodulatory, and anti-cancer activities.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98%
- CAS 番号: 936541-36-5
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Lactoferrin (0-1 000 μg/mL, 7 days) inhibits epithelial cell (HaCaT) growth in a dose-dependent manner[1].
Lactoferrin (500 μg/mL, 12 days) inhibits the spreading and growth of HaCaT cell colonies[1].
Lactoferrin (1.41 μM and 0.12 μM for human and bovine Lactoferrins) inhibits HSV-1 infection in vero cells by 50%[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Lactoferrin (Bovine lactoferrin) (100 and 200 mg/kg, oral gavage,for 30 consecutive days) shows protective effects in a rat model of sepsis-induced acute lung injury[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Squamous cell carcinoma model (O12 cell injected into the left flank of nu/numice)[5]
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Dosage:1,000 mg/kg
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Administration:oral gavage, twice daily for 8 days
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Result:Inhibited the tumor growth by 80%.
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Animal Model:Sepsis-induced acute lung injury rat model[6]
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Dosage:100 and 200 mg/kg
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Administration:oral gavage,for 30 consecutive days
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Result:Reduced the wet/dry ratio of lung tissue by 30.7% and 61.3%, and lipid peroxidation by 22.3% and 67%, at concentrations of 100 and 200mg/kg.
Reduced Inflammatory markers, neutrophils, lymphocytes and total cell count.
Reduced MPO activity.
化学情報
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CAS 番号 936541-36-5
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性状 Solid
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Color Off-white to pink
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SMILES
[Lactoferrin from Bovine milk]
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別名
ラクトフェリン
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
H2O : ≥ 50 mg/mL
* "≥" means soluble, but saturation unknown.
純度とドキュメンテーション
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データシート (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Pöllänen MT, et al. Lactoferrin impedes epithelial cell adhesion in vitro. J Periodontal Res. 1998 Jan;33(1):8-16. [Content Brief]
[2]. Berlutti F, et al. Antiviral properties of lactoferrin--a natural immunity molecule. Molecules. 2011 Aug 16;16(8):6992-7018. [Content Brief]
[3]. Cutone A, et al. Lactoferrin's Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action. Biomolecules. 2020 Mar 15;10(3):456. [Content Brief]
[4]. Marchetti M, et al. Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells. Antiviral Res. 1996 Mar;29(2-3):221-31. [Content Brief]
[5]. Varadhachary A, et al. Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy. Int J Cancer. 2004 Sep 1;111(3):398-403. [Content Brief]
[6]. Han N, et al. Effect of bovine lactoferrin as a novel therapeutic agent in a rat model of sepsis-induced acute lung injury. AMB Express. 2019 Oct 31;9(1):177. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lactoferrin from Bovine milk 関連分類
HY-P3161 関連分類
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