LK-2
Based on 1 Customer Validation
LK-2 is an antagonist for ASIC1a with a Kd of 1.9 μM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 μM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.83%
- CAS 番号: 2649762-09-2
- 分子式: C12H17N2O5P
- 分子量:300.25
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
| Species | Dose | Route | Cmax | Cmax (Brain) | T1/2 (Elimination) |
|---|---|---|---|---|---|
| Mice[1] | 30 mg/kg | i.p. | 92660 μg/L | 236 μg/L | 2.297 h |
化学情報
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CAS 番号 2649762-09-2
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性状 Solid
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分子量 300.25
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分子式 C12H17N2O5P
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Color White to off-white
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SMILES
OP(C(C1=CC=CC=C1)N2CC(C(O)=O)NCC2)(O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
H2O : 50 mg/mL (166.53 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.3306 mL | 16.6528 mL | 33.3056 mL | 83.2639 mL |
| 5 mM | 0.6661 mL | 3.3306 mL | 6.6611 mL | 16.6528 mL | |
| 10 mM | 0.3331 mL | 1.6653 mL | 3.3306 mL | 8.3264 mL | |
| 15 mM | 0.2220 mL | 1.1102 mL | 2.2204 mL | 5.5509 mL | |
| 20 mM | 0.1665 mL | 0.8326 mL | 1.6653 mL | 4.1632 mL | |
| 25 mM | 0.1332 mL | 0.6661 mL | 1.3322 mL | 3.3306 mL | |
| 30 mM | 0.1110 mL | 0.5551 mL | 1.1102 mL | 2.7755 mL | |
| 40 mM | 0.0833 mL | 0.4163 mL | 0.8326 mL | 2.0816 mL | |
| 50 mM | 0.0666 mL | 0.3331 mL | 0.6661 mL | 1.6653 mL | |
| 60 mM | 0.0555 mL | 0.2775 mL | 0.5551 mL | 1.3877 mL | |
| 80 mM | 0.0416 mL | 0.2082 mL | 0.4163 mL | 1.0408 mL | |
| 100 mM | 0.0333 mL | 0.1665 mL | 0.3331 mL | 0.8326 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
LK-2 関連分類
HY-164284 関連分類
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