mTOR inhibitor-2
mTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC50 of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2219323-96-1
- 分子式: C23H21N7O
- 分子量:411.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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mTOR 7 nM (IC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
441 nM
Compound: 9m
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Growth inhibition of human HeLa cells after 72 hrs by CCK8 assay
Growth inhibition of human HeLa cells after 72 hrs by CCK8 assay
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[PMID: 29308895] |
| MCF7 | IC50 |
103 nM
Compound: 9m
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Growth inhibition of human MCF7 cells after 72 hrs by CCK8 assay
Growth inhibition of human MCF7 cells after 72 hrs by CCK8 assay
|
[PMID: 29308895] |
| MDA-MB-231 | IC50 |
100 nM
Compound: 9m
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Growth inhibition of human MDA-MB-231 cells after 72 hrs by CCK8 assay
Growth inhibition of human MDA-MB-231 cells after 72 hrs by CCK8 assay
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[PMID: 29308895] |
| NCI-H460 | IC50 |
1775 nM
Compound: 9m
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Growth inhibition of human H460 cells after 72 hrs by CCK8 assay
Growth inhibition of human H460 cells after 72 hrs by CCK8 assay
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[PMID: 29308895] |
| OVCAR-5 | IC50 |
2831 nM
Compound: 9m
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Growth inhibition of human OVCAR5 cells after 72 hrs by CCK8 assay
Growth inhibition of human OVCAR5 cells after 72 hrs by CCK8 assay
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[PMID: 29308895] |
| SiHa | IC50 |
110 nM
Compound: 9m
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Growth inhibition of human SiHa cells after 72 hrs by CCK8 assay
Growth inhibition of human SiHa cells after 72 hrs by CCK8 assay
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[PMID: 29308895] |
| SK-OV-3 | IC50 |
1850 nM
Compound: 9m
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Growth inhibition of human SKOV3 cells after 72 hrs by CCK8 assay
Growth inhibition of human SKOV3 cells after 72 hrs by CCK8 assay
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[PMID: 29308895] |
| T47D | IC50 |
205 nM
Compound: 9m
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Growth inhibition of human T47D cells after 72 hrs by CCK8 assay
Growth inhibition of human T47D cells after 72 hrs by CCK8 assay
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[PMID: 29308895] |
化学情報
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CAS 番号 2219323-96-1
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分子量 411.46
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分子式 C23H21N7O
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SMILES
O=C(N1C2CCN(CC#N)CC2)C=NC3=C1C4=CC(C5=CN=C(N)C=C5)=CC=C4N=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
mTOR inhibitor-2 関連分類
HY-111370 関連分類
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