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製品番号: HY-24504

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MBA-m1

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Based on 1 Customer Validation

MBA-m1 is a reversible non-covalent allosteric inhibitor of mMLKL2, with a K_d value of 6 μM for mMLKL2. MBA-m1 delays Necroptosis. MBA-m1 has no effect on the activities of RIPK1 or RIPK3. MBA-m1 alleviates skin injury, epidermal thickening and immune cell infiltration in dermatitis models, and reduces aortic diameter enlargement and structural changes in abdominal aortic aneurysm models. MBA-m1 can be used in research related to dermatitis and abdominal aortic aneurysm.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.20%
CAS 番号: 305866-70-0
分子式: C₂₇H₂₁ClN₂O₂
分子量:440.92

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MBA-m1 構造式

CAS 番号: 305866-70-0

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Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	7.07 μM Compound: GNF-Pf-2622	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	[PMID: 18579783]
SK-BR-3	IC₅₀	5 μM Compound: 33	Cytotoxicity against human SKBr3 cells after 72 hrs by MTT assay Cytotoxicity against human SKBr3 cells after 72 hrs by MTT assay	[PMID: 18500794]

体外実験

MBA-m1 (10 μM) potently delays TSZ-induced necroptosis in wild-type mouse NIH-3T3 cells by inhibiting mMLKL activation and downstream cell death processes^[1].
MBA-m1 directly binds to purified recombinant mouse mMLKL2 protein, and this conclusion is confirmed by isothermal titration calorimetry^[1].
MBA-m1 (10 μM; 1 h pre-treatment) binds to mMLKL in wild-type mouse NIH-3T3 cells, which is confirmed by the increased thermal stability of mMLKL in cellular thermal shift assay^[1].
MBA-m1 (12.5-200 μM) binds to recombinant mouse MLKL (mMLKL2) with a K_d value of 6 μM^[2].
MBA-m1 (4-8 h post TSZ treatment; 1-10 μM) dose-dependently delays the necroptosis kinetics of NIH-3T3 cells^[2].
MBA-m1 (5-10 μM; 0-24 h post-TS treatment) does not affect RIPK1-mediated extrinsic apoptosis in wild-type or MLKL-knockout NIH-3T3 cells, which supports its specificity for MLKL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

wild-type and MLKL knockout NIH-3T3 cells
Concentration:

5, 10 μM
Incubation Time:

0-24 h (post-TS treatment)
Result:

Had no discernible effect on the kinetics of RIPK1-mediated extrinsic apoptosis in either wild-type or MLKL knockout NIH-3T3 cells.

体内実験

MBA-m1 (30 mg/kg; i.p.; every other day; 21 days) significantly ameliorates MLKL-driven dermatitis in Tnfr1^-/-;Hoip^E-KO mice, reducing skin inflammation severity, epidermal thickness, and immune cell infiltration^[1].
MBA-m1 (30 mg/kg; i.p.; every other day; 18 days) significantly attenuates abdominal aortic aneurysm progression in mice, reducing aortic dilation, structural damage, and immune cell infiltration^[1].
MBA-m1 significantly reduces dermatitis severity and disease progression in a necroptosis-driven mouse dermatitis model^[2].
MBA-m1 prevents aortic aneurysm development in a porcine pancreatic elastase-induced mouse model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6N mice (30-40 days old)^[1]
Dosage:

30 mg/kg
Administration:

i.p.; every other day; 21 days
Result:

Significantly ameliorated dermatitis with patches of healthy and moderately inflamed dorsal skin.
Reduced epidermal thickness compared to vehicle controls.
Decreased CD45-positive cell infiltration in both healthy and inflamed tissue compared to vehicle controls.
Lowered dermatitis severity scores at study endpoint compared to vehicle controls.

化学情報

CAS 番号 305866-70-0
性状 Solid
分子量 440.92
分子式 C₂₇H₂₁ClN₂O₂
Color White to off-white
SMILES

ClC1=CC(NC2=CC(C)=NC3=C2C=C(OC)C=C3)=CC=C1OC4=CC5=C(C=CC=C5)C=C4
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ros U, et al. MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Molecular cell. 2025 Apr 17;85(8):1589-1605.e12. [Content Brief]

[2]. Abdelwahab Y. Development of a New Class of Necroptosis Inhibitors That Bind Allosterically to Human and Mouse MLKL[D]. Universität zu Köln, 2025.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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生物活性
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- 体内実験
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純度とドキュメンテーション
参考文献

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MBA-m1

High-Throughput Bioactive Compound Library

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

MBA-m1 関連分類

HY-24504 関連分類