MC0704
Based on 1 Customer Validation
MC0704 is a STAT3 inhibitor with an IC50 value of 2.13 μM. MC0704 induces cell apoptosis and cell cycle arrest. MC0704 shows antitumor activity in mouse breast cancer models. MC0704 can be used for the research of metastatic triple-negative breast cancer (mTNBC).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.34%
- CAS 番号: 3034176-57-0
- 分子式: C29H21BrN4O2
- 分子量:537.41
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
2.96 μM
Compound: MC0704
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Antiproliferative activity against docetaxel-resistant human MDA-MB-231-DTR cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay
Antiproliferative activity against docetaxel-resistant human MDA-MB-231-DTR cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay
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[PMID: 36786551] |
| MDA-MB-231 | IC50 |
2.98 μM
Compound: MC0704
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 36786551] |
| MDA-MB-231 | IC50 |
3.11 μM
Compound: MC0704
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay
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[PMID: 36786551] |
| MDA-MB-231 | IC50 |
3.24 μM
Compound: MC0704
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Antiproliferative activity against docetaxel-resistant human MDA-MB-231-DTR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against docetaxel-resistant human MDA-MB-231-DTR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 36786551] |
| MRC5 | IC50 |
33.25 μM
Compound: MC0704
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay
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[PMID: 36786551] |
MC0704 (0-50 μM; 72 h) shows cytotoxicity to HEK-293, lung epithelial normal (MRC-5), MDA-MB 231, MDA-MB-231 paclitaxel-resistant (MDA-MB-231-PTR) and MDA-MB-231 docetaxel-resistant (MDA-MB-231-DTR) cells with IC50 values of 3.11, 33.25, 2.98, 3.24 and 2.87 μM, respectively[1]. MC0704 (0, 0.4, 2, 10 and 50 μM; 24 h) inhibits activity of STAT3 with an IC50 value of 2.13 μM[1]. MC0704 (5 μM; 24 h) suppresses the activation of STAT3[1]. MC0704 (0, 2.5, 5 and 10 μM; 36-48 h) increases the cell cycle arrest at the G2/M phase and induces apoptosis in MDA-MB-231-DTR cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK-293 and MRC-5 cell lines
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Concentration:0-50 μM
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Incubation Time:72 hours
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Result:Showed cytotoxicity to HEK-293 and MRC-5 cells.
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Cell Line:MDA-MB-231 TNBC cell line
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Concentration:5 μM
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Incubation Time:24 hour
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Result:Inhibited the expression of p-STAT3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c-nu mice with MDA-MB-231-DTR cells transplant[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; 10 mg/kg, once daily for 12 days
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Result:Significantly inhibited tumor growth without overt toxicity, and reversed the mesenchymal marker vimentin and epithelial marker E-cadherin expression changes.
化学情報
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CAS 番号 3034176-57-0
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性状 Solid
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分子量 537.41
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分子式 C29H21BrN4O2
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Color Light yellow to yellow
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SMILES
O=C(C1=NC(C(NCCC2=CNC3=C2C=CC=C3)=O)=CC4=C1NC5=CC=CC=C54)C6=CC=C(C=C6)Br
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (46.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (251 KB)
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- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8608 mL | 9.3039 mL | 18.6078 mL | 46.5194 mL |
| 5 mM | 0.3722 mL | 1.8608 mL | 3.7216 mL | 9.3039 mL | |
| 10 mM | 0.1861 mL | 0.9304 mL | 1.8608 mL | 4.6519 mL | |
| 15 mM | 0.1241 mL | 0.6203 mL | 1.2405 mL | 3.1013 mL | |
| 20 mM | 0.0930 mL | 0.4652 mL | 0.9304 mL | 2.3260 mL | |
| 25 mM | 0.0744 mL | 0.3722 mL | 0.7443 mL | 1.8608 mL | |
| 30 mM | 0.0620 mL | 0.3101 mL | 0.6203 mL | 1.5506 mL | |
| 40 mM | 0.0465 mL | 0.2326 mL | 0.4652 mL | 1.1630 mL |
MC0704 関連分類
HY-148923 関連分類
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