MD6a
MD6a is a melatonin derivative with inhibitroy activity towards PARP-1, which maintains proteins hemostasis and improves mitochondrial function through TOR/HSF-1 signaling. MD6a a neuroprotective effect.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C21H22N2O2
- 分子量:334.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MD6a (10 μM) inhibits PARP-1 to downregulate let-363/hsf-1 signaling by targeting hsp-4 and hsp-6, thus reducing α-syn aggregation and enhances mitochondrial function in C. elegans[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:wildtype N2, NL5901, parp-1 RNAi
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Concentration:10 μM
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Incubation Time:48 h
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Result:Reduced levels of parp-1 mRNA, parp-1 dependent α-syn aggregation and mitochondrial ROS levels.
化学情報
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分子量 334.41
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分子式 C21H22N2O2
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SMILES
COC1=CC(/C=C/C2=CC=CC=C2)=C(NC=C3CCNC(C)=O)C3=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MD6a 関連分類
HY-162363 関連分類
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