Menadiol (Standard)
Menadiol (Standard) (Dihydrovitamin K3 (Standard)) is the analytical standard of Menadiol (HY-W128525). This product is intended for research and analytical applications. Menadiol (Dihydrovitamin K3) is a menadione analog that acts as an electron donor. Menadiol transfers electrons to the heme bL of E. coli nitrate reductase A and, via heme bH, to the catalytic NarGH dimer. Menadiol drives ATP-dependent NAD⁺ reduction (reverse electron transport) in submitochondrial particles. Menadiol selectively inhibits the growth of lymphoid tumor cells. Menadiol enhances the growth-inhibitory effects of Mechlorethamine, Vincristine (HY-N0488A), and Dexamethasone (HY-14648) on tumor cells, converting a drug-resistant phenotype to a sensitive phenotype. Menadiol is used in research related to lymphoid tumors.
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- CAS 番号: 481-85-6
- 分子式: C11H10O2
- 分子量:174.20
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 481-85-6
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分子量 174.20
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分子式 C11H10O2
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SMILES
CC1=C(C2=CC=CC=C2C(=C1)O)O
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別名
Dihydrovitamin K3 (Standard)
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Zhao Z, et al. Effects of site-directed mutations on heme reduction in Escherichia coli nitrate reductase A by menaquinol: a stopped-flow study. Biochemistry. 2003 Dec 09;42(48):14225-33. [Content Brief]
[2]. Taggart WV, et al. Menadiol as an electron donor for reversed oxidative phosphorylation in submitochondrial particles. Biochim Biophys Acta. 1972 Jun 23;267(3):439-43. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Keywords
- Menadiol (Standard)
- 481-85-6
- Dihydrovitamin K3 (Standard)
- Reference Standards
- Mitochondrial Metabolism
- Oxidative Phosphorylation
- mitochondrial respiratory chain
- NarGH dimer
- human lymphatic neoplasm cells
- heme b_L
- menadione semiquinone radical anion
- E. coli nitrate reductase A
- reversed electron flow
- heme b_H
- bovine heart submitochondrial particles
- menaquinol analogue
- Inhibitor
- inhibitor
- inhibit