Metanephrine
Based on 1 Customer Validation
Metanephrine is the O-methylated metabolite of epinephrine that can be used for the research of diagnosis of pheochromocytoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.75%
- CAS 番号: 5001-33-2
- 分子式: C10H15NO3
- 分子量:197.23
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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Help & FAQs
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
Metanephrine inhibits MPP+ uptake into Caki-1 cells and rat hepatocytes with IC50s of 34.2 µM and 302.0 µM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 5001-33-2
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性状 Solid
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分子量 197.23
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分子式 C10H15NO3
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Color White to off-white
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SMILES
OC(CNC)C1=CC=C(O)C(OC)=C1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 20 mg/mL (101.40 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Eisenhofer G, et al. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem. 2011 Mar;57(3):411-20. [Content Brief]
[2]. Martel F, et al. Comparison between uptake2 and rOCT1: effects of catecholamines, metanephrines and corticosterone. Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):303-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.0702 mL | 25.3511 mL | 50.7022 mL | 126.7556 mL |
| 5 mM | 1.0140 mL | 5.0702 mL | 10.1404 mL | 25.3511 mL | |
| 10 mM | 0.5070 mL | 2.5351 mL | 5.0702 mL | 12.6756 mL | |
| 15 mM | 0.3380 mL | 1.6901 mL | 3.3801 mL | 8.4504 mL | |
| 20 mM | 0.2535 mL | 1.2676 mL | 2.5351 mL | 6.3378 mL | |
| 25 mM | 0.2028 mL | 1.0140 mL | 2.0281 mL | 5.0702 mL | |
| 30 mM | 0.1690 mL | 0.8450 mL | 1.6901 mL | 4.2252 mL | |
| 40 mM | 0.1268 mL | 0.6338 mL | 1.2676 mL | 3.1689 mL | |
| 50 mM | 0.1014 mL | 0.5070 mL | 1.0140 mL | 2.5351 mL | |
| 60 mM | 0.0845 mL | 0.4225 mL | 0.8450 mL | 2.1126 mL | |
| 80 mM | 0.0634 mL | 0.3169 mL | 0.6338 mL | 1.5844 mL | |
| 100 mM | 0.0507 mL | 0.2535 mL | 0.5070 mL | 1.2676 mL |
Metanephrine 関連分類
HY-113299 関連分類
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