製品番号: HY-N1482

パルミチン酸メチル

(別名: Methyl palmitate)

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Methyl palmitate is a naturally occurring fatty acid ester. Methyl palmitate is a potent inhibitor of ΙκB phosphorylation. Methyl palmitate modulates macrophage activity and down-regulates pro-inflammatory mediators such as TNF-α and nitric oxide (NO). Methyl palmitate possesses anti-inflammatory and antifibrotic effects. Methyl palmitate can inhibit LPS (HY-D1056)-induced Kupffer cells and rat peritoneal macrophages. Methyl palmitate is able to inhibit the phagocytic function of RAW cells. Methyl palmitate is antagonistic to muscarinic receptors. Methyl palmitate exerts cardioprotective effects against ischemia/reperfusion injury in vivo. Methyl palmitate is highly toxic against adult T. cinnabarinus.

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純度: 98.0%
CAS 番号: 112-39-0
分子式: C₁₇H₃₄O₂
分子量:270.45

保管条件:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Methyl palmitate 構造式

CAS 番号: 112-39-0

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

Methyl palmitate (Compound MP) (0.25-1 mM, 24 h) reduces the phagocytic activity and nitrite production dose-dependently in RAW cells^[1].
Methyl palmitate (75 μM) significantly reduces the I/R-decreased cell viability in cardiomyocytes and increases the level of p-AKT^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

RAW cells
Concentration:

0.5 mM
Incubation Time:

24 h
Result:

Significantly decreased TNF-α release and inhibited the expression of NF-κB.

体内実験

Methyl palmitate (Compound MP) (75-150 mg/kg, i.p., single dose) significantly reduces Carrageenan (HY-125474)-induced paw edema in Wistar rats^[4].
Methyl palmitate (150 mg/kg, i.p., single dose) significantly inhibits IL-6 and TNF-α in Wistar rats^[4].
Methyl palmitate (300 mg/kg, i.v., 5 min before reperfusion) attenuates the I/R-induced myocardium infarct size and significantly reduces the level of CK-MB in I/R-injured heart cardiomyocytes of rat model^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 112-39-0
性状 <32°C Solid,>35°C Liquid
分子量 270.45
分子式 C₁₇H₃₄O₂
Color Colorless to off-white
SMILES

CCCCCCCCCCCCCCCC(OC)=O
別名

Methyl palmitate
Structure Classification
- Lipids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (184.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (184.88 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.6975 mL

18.4877 mL

36.9754 mL

5 mM

0.7395 mL

3.6975 mL

7.3951 mL

10 mM

0.3698 mL

1.8488 mL

3.6975 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (9.24 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (9.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 30 mg/mL (110.93 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. El-Demerdash E, et al, Anti-inflammatory and antifibrotic effects of methyl palmitate. Toxicol Appl Pharmacol. 2011 Aug 1;254(3):238-44. [Content Brief]

[2]. N. R. Di Luzio, et al. Depression of phagocytic activity and immune response by methyl palmitate. Am J Physiol. 1964 May;206:939-43. [Content Brief]

[3]. Y. N. Wang, et al. Methyl Palmitate, an Acaricidal Compound Occurring in Green Walnut Husks. Journal of Economic Entomology, Volume 102, Issue 1, 1 February 2009, Pages 196–202.

[4]. Saeed, N. M., et al., (2012). Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models. Toxicology and applied pharmacology, 264(1), 84–93. [Content Brief]

[5]. Shen, Y. J., et al., (2021). Methyl palmitate protects heart against ischemia/reperfusion-induced injury through G-protein coupled receptor 40-mediated activation of the PI3K/AKT pathway. European journal of pharmacology, 905, 174183. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	3.6975 mL	18.4877 mL	36.9754 mL	92.4385 mL
	5 mM	0.7395 mL	3.6975 mL	7.3951 mL	18.4877 mL
	10 mM	0.3698 mL	1.8488 mL	3.6975 mL	9.2439 mL
	15 mM	0.2465 mL	1.2325 mL	2.4650 mL	6.1626 mL
	20 mM	0.1849 mL	0.9244 mL	1.8488 mL	4.6219 mL
	25 mM	0.1479 mL	0.7395 mL	1.4790 mL	3.6975 mL
	30 mM	0.1233 mL	0.6163 mL	1.2325 mL	3.0813 mL
	40 mM	0.0924 mL	0.4622 mL	0.9244 mL	2.3110 mL
	50 mM	0.0740 mL	0.3698 mL	0.7395 mL	1.8488 mL
	60 mM	0.0616 mL	0.3081 mL	0.6163 mL	1.5406 mL
	80 mM	0.0462 mL	0.2311 mL	0.4622 mL	1.1555 mL
	100 mM	0.0370 mL	0.1849 mL	0.3698 mL	0.9244 mL

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Parasite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Methyl palmitate 関連分類

製品番号: HY-N1482