ML243
ML243 is a selective small-molecule inhibitor of breast cancer stem cells. ML243 has 32-fold greater selective inhibition in the breast CSC-like cell line HMLE_shECad than the control cell line HMLE_shGFP. ML243 may target the Wnt pathway at the protein level without altering RNA expression levels.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1426576-80-8
- 分子式: C14H16N2OS
- 分子量:260.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
Breast CSCs[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HMLE | EC50 |
2 μM
Compound: 19d, ML243
|
Cytotoxicity against human CSC-like HMLE cells expressing shRNA and epithelial cadherin after 70 to 74 hrs by Cell Titer Glo assay
Cytotoxicity against human CSC-like HMLE cells expressing shRNA and epithelial cadherin after 70 to 74 hrs by Cell Titer Glo assay
|
[PMID: 23403082] |
| HMLE | EC50 |
63.98 μM
Compound: 19d, ML243
|
Cytotoxicity against human HMLE cells expressing shRNA and GFP after 70 to 74 hrs by Cell Titer Glo assay
Cytotoxicity against human HMLE cells expressing shRNA and GFP after 70 to 74 hrs by Cell Titer Glo assay
|
[PMID: 23403082] |
化学情報
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CAS 番号 1426576-80-8
-
分子量 260.35
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分子式 C14H16N2OS
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SMILES
CCC1=CC=C(/C=C/C(NC2=NCCS2)=O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)