MPX-004
Based on 1 Customer Validation
MPX-004 is a potent GluN2A antagonist. MPX-004 inhibits GluN2A-containing NMDA receptors expressed in HEK cells with an IC50 of 79 nM. MPX-004 has no inhibitory effect on GluN2B or GluN2D receptor-mediated responses. MPX-004 has the potential for neuropsychiatric and developmental disorders research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.58%
- CAS 番号: 1688684-07-2
- 分子式: C17H15ClFN5O3S2
- 分子量:455.91
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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iGluR アイソフォーム固有の製品をすべて表示
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生物活性
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5-HT1B Receptor |
NMDA Receptor |
MPX-004 inhibits NMDA receptor-mediated currents in Xenopus oocytes expressing human GluN1 + GluN2A with an IC50 of 198 nM. At 10 μM, MPX-004 only weakly (up to 8%) inhibits currents in oocytes expressing GluN2B, C, or D receptors or in control oocytes[1].
MPX-004 (100 nM-30 μM; 0-50 min) causes a concentration-dependent reduction in NMDA receptor-mediated fEPSPs in region CA1 in response to Schaffer collateral stimulation in hippocampal slices prepared from brains of 3- to 4-week old rats[1].
MPX-004 (1 μM) inhibits 5-HT1B antagonist binding by 35%, 5-HT2A agonist binding by 31% and EP4 agonist binding by 27%. MPX-004 (50 μM) has no effect on AMPA receptor-mediated synaptic currents of pyramidal neurons in slices from mouse visual cortex- currents[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1688684-07-2
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性状 Solid
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分子量 455.91
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分子式 C17H15ClFN5O3S2
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Color White to light yellow
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SMILES
O=C(C1=NC=C(CNS(=O)(C2=CC=C(C(Cl)=C2)F)=O)N=C1)NCC3=CN=C(C)S3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MPX-004 関連分類
HY-148939 関連分類
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