MRL20
MRL20 is a PPARγ constitutive and allosteric agonist. MRL20 enhances the interaction between PPARγ and the co-activating peptide of TRAP220, with its EC50 being 10 nM. Even after being covalently blocked in the constitutive pocket by GW9662 (HY-16578) or T0070907 (HY-13202), MRL20 can still strengthen the interaction between PPARγ and TRAP220, with EC50 values of 176 and 440 nM respectively. MRL20 fails to completely inhibit its cell activation effect. MRL20 can be used to study the allosteric regulatory mechanism of PPARγ.
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- CAS 番号: 393794-32-6
- 分子式: C28H24F3NO6
- 分子量:527.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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PPAR-γ 10 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-1 | EC50 |
0.002 μM
Compound: 20
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In vitro maximal activation of human Peroxisome proliferator activated receptor gamma in COS-1 cell transactivation assay
In vitro maximal activation of human Peroxisome proliferator activated receptor gamma in COS-1 cell transactivation assay
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[PMID: 15603954] |
化学情報
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CAS 番号 393794-32-6
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分子量 527.49
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分子式 C28H24F3NO6
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SMILES
O=C(C1=CC=C(C=C1)OC)N2C3=CC=C(OC(F)(F)F)C=C3C(CC4=C(C=CC=C4)O[C@@H](C)C(O)=O)=C2C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MRL20 関連分類
HY-122222 関連分類
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