Myoglobin
Based on 1 Customer Validation
Myoglobin is an oxygen-binding heme protein. Myoglobin scavenges ROS via its peroxidase activity, and binds to and inactivates NO in the heart and oxidative skeletal muscle. Myoglobin stores, buffers and facilitates intracellular oxygen diffusion, maintains aerobic metabolism under hypoxic/anoxic conditions, and provides oxygen supply support for mitochondria. Myoglobin alleviates oxidative stress, protects cardiac function and affects cardiac redox pathways. Myoglobin can be used in studies related to ischemia-reperfusion injury, oxidative stress-induced cardiac dysfunction and acute myocardial infarction.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.00%
- CAS 番号: 100684-32-0
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Myoglobin undergoes redox cycling in vitro upon exposure to oxygen free radicals or peroxides[3].
Myoglobin reacts with NO through multiple pathways, among which the direct reaction between oxymyoglobin and NO proceeds at the fastest rate, with a rate constant of 3.7 × 107 M-1·s-1, enabling efficient scavenging of NO[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 100684-32-0
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性状 Solid
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Color Brown to reddish brown
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SMILES
[Myoglobin]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
H2O : < 0.1 mg/mL (insoluble)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ordway GA, et al. Myoglobin: an essential hemoprotein in striated muscle. The Journal of experimental biology. 2004 Sep;207(Pt 20):3441-6. [Content Brief]
[2]. Baron CP, et al. Myoglobin-induced lipid oxidation. A review. Journal of agricultural and food chemistry. 2002 Jul 03;50(14):3887-97. [Content Brief]
[3]. Flögel U, et al. Role of myoglobin in the antioxidant defense of the heart. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004 Jul;18(10):1156-8. [Content Brief]
[4]. Flögel U, et al. Myoglobin: A scavenger of bioactive NO. Proceedings of the National Academy of Sciences of the United States of America. 2001 Jan 16;98(2):735-40. [Content Brief]
[5]. Gibler WB, et al. Myoglobin as an early indicator of acute myocardial infarction. Annals of emergency medicine. 1987 Aug;16(8):851-6. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Myoglobin 関連分類
HY-NP007 関連分類
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